Analysis of contractile properties of muscles from rats immunized with purified acetylcholine receptor

Colleen A. Olsberg, Leo C. Maxwell, Terry M. Mikiten, Keith A. Krolick

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Experimental autoimmune myasthenia gravis (EAMG) was induced in rats by injection of purified acetylcholine receptor (AChR). In addition to detecting elevated serum titers of anti-AChR antibodies, we observed decreased twitch-tension at submaximal stimulation voltages and increased curare sensitivity by muscles obtained from immunized rats when compared to muscles obtained from nonimmune control rats. Furthermore, antibody-induced neuromuscular impairment was expressed to differing extents dependent on whether the diaphragm, soleus, or extensor digitorum longus muscle was examined. Thus, we conclude that potential antibody perturbation of AChR function will depend not only on the nature of the antibody, but also on the complex structure-function relationships that exist in individual muscles. This may partially explain the variable impairment of different muscle groups in patients with myasthenia.

Original languageEnglish (US)
Pages (from-to)253-266
Number of pages14
JournalJournal of Neuroimmunology
Volume14
Issue number3
DOIs
StatePublished - Apr 1987

Keywords

  • Acetylcholine receptor
  • Autoimmunity
  • Muscle contraction
  • Myasthenia gravis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Analysis of contractile properties of muscles from rats immunized with purified acetylcholine receptor'. Together they form a unique fingerprint.

  • Cite this