Analysis of 130 Cases of Sympathetic Ophthalmia–A Retrospective Multicenter Case Series

Xiu Ling Tan, Sophia Seen, Parthopratim Dutta Majumder, Sudha K. Ganesh, Mamta Agarwal, Aniruddh Soni, Jyotirmay Biswas, Kanika Aggarwal, Padmamalini Mahendradas, Vishali Gupta, Ho Su Ling, Stephen Teoh, Carlos Pavesio, Rupesh Agrawal

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Objective: To analyze the demographic profile, treatment, and visual outcome of the patients with sympathetic ophthalmia (SO) in a multicenter collaborative retrospective cohort study. Methods: Medical records of the patients with SO from UK, Singapore, India were reviewed for history of ocular trauma or surgery and subsequent development of uveitis consistent with SO, presenting symptoms, treatment, and visual outcomes. Results: A total of 130 patients were diagnosed with SO during the study period. Eighty-one (62.3%) patients were men. The mean age was 48.4 ± 15.5 years. The most common presenting symptom was blurring of vision (89.2%), followed by pain (29.2%) and floaters (23.8%). Ninety-two (70.7%) required additional immunosuppressive therapy. Thirty-six (27.9%) patients underwent enucleation of the inciting eye. Conclusions: SO is a potentially sight-threatening disease with high rates of visual loss. It warrants prompt evaluation and treatment. With the advances and availability in immunotherapy, the visual prognosis is relatively good.

Original languageEnglish (US)
Pages (from-to)1259-1266
Number of pages8
JournalOcular Immunology and Inflammation
Issue number8
StatePublished - Nov 17 2019
Externally publishedYes


  • Corticosteroids
  • enucleation
  • immunosuppressive therapy
  • phthisis bulbi
  • sympathetic ophthalmia
  • trauma

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology


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