Analysis for lead in undiluted whole blood by tantalum ribbon atomic absorption spectrophotometry

B. L. Therrell, J. M. Drosche, T. W. Dziuk

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


We describe a modified tantalum ribbon atomic absorption procedure for determining lead in undiluted whole blood. An Instrumentation Laboratory (I.L.) Model 151 atomic absorption spectrophotometer equipped with an I.L. Model 355 Flameless Sampler was used. The Flameless Sampler was slightly modified to include three cycle operation instead of the normal two cycles. This modified single-beam system, equipped with background correction, allows 5-μl specimens of whole blood to be quickly and accurately analyzed. No sample preparation other than vortex mixing is involved and method reliability has been demonstrated during an extended period of successful participation in proficiency testing studies conducted by the Center for Disease Control. This tantalum ribbon methodology has further been demonstrated to be effective both as a primary screening procedure and as a confirmatory procedure, when coupled with erythrocyte protoporphyrin determinations, in screening over 300 000 clients during a three year period of use in the Early and Periodic Screening, Diagnosis and Treatment (EPSDT) Program in Texas.

Original languageEnglish (US)
Pages (from-to)1182-1185
Number of pages4
JournalClinical Chemistry
Issue number7
StatePublished - 1978
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical


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