Analgesic effects of phencyclidine-like drugs in rhesus monkeys

Charles P France, A. M. Snyder, J. H. Woods

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Analgesic and discriminative stimulus effects of phencyclidine (PCP), ketamine, dextrorphan, (+)-N-allyl-normetazocine [(+)-SKF 10,047] and (+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-amine maleate (MK-801) were studied in rhesus monkeys. All five compounds increased in a dose-related manner the latency for monkeys to remove their tails from warm water with the order of potency being MK-801 > PCP > ketamine > (+)-SKF 10,047 > dextrorphan. Moreover, these effects were temperature-dependent with larger doses required to produce a maximum response when higher temperatures (i.e., 55°C) were studied. The effects of PCP, ketamine, dextrorphan, (+)-SKF 10,047 and MK-801 were not attenuated by a dose (1.0 mg/kg) of the opioid antagonist quadazocine that antagonized the analgesic effects of the opioid mu agonist alfentanil and kappa agonist U-50,488, MK-801, PCP, (+)-SKF 10,047 and dextrorphan also substituted in a dose-related manner for the ketamine discriminative stimulus (1.78 mg/kg) and their relative potency as discriminative stimuli was the same as their relative potency in the tail withdrawal procedure. The apparent analgesic effects of PCP-like drugs occurred at doses 2- to 8-fold larger than doses required for discriminative stimulus effects and 3- to 10-fold smaller than doses required for anesthesia. These results support the notion that PCP-like drugs produce analgesic effects at subanesthetic doses. Moreover, the analgesic effects of PCP and related drugs in rhesus monkeys were not mediated by actions at the opioid receptors known to be associated with analgesia.

Original languageEnglish (US)
Pages (from-to)197-201
Number of pages5
JournalJournal of Pharmacology and Experimental Therapeutics
Volume250
Issue number1
StatePublished - 1989
Externally publishedYes

Fingerprint

Dextrorphan
Phencyclidine
Dizocilpine Maleate
Ketamine
Macaca mulatta
Analgesics
Pharmaceutical Preparations
Tail
Alfentanil
Temperature
Narcotic Antagonists
Opioid Receptors
Analgesia
Opioid Analgesics
Amines
Haplorhini
Anesthesia
Water

ASJC Scopus subject areas

  • Pharmacology

Cite this

Analgesic effects of phencyclidine-like drugs in rhesus monkeys. / France, Charles P; Snyder, A. M.; Woods, J. H.

In: Journal of Pharmacology and Experimental Therapeutics, Vol. 250, No. 1, 1989, p. 197-201.

Research output: Contribution to journalArticle

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