Analgesic, anesthetic, and respiratory effects of the competitive N-methyl-d-aspartate (NMDA) antagonist CGS 19755 in rhesus monkeys

Charles P. France; Gail D. Winger; James H. Woods

doi:10.1016/0006-8993(90)91247-E

Analgesic, anesthetic, and respiratory effects of the competitive N-methyl-d-aspartate (NMDA) antagonist CGS 19755 in rhesus monkeys

Charles P. France, Gail D. Winger, James H. Woods

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

The competitive excitatory amino acid antagonist cis-4-phosphonomethyl-2-piperidine-carboxylic acid (CGS 19755) increased the latency for monkeys to remove their tails from warm water (analgesia); larger doses produced ataxia, loss of righting, salivation, and eliminated reactivity to stimulation (anasthesia). CGS 19755 decreased tidal volume and had little effect on frequency of respiration. Although longer lasting, the effects of CGS 19755 were similar to the effects of ketamine, suggesting these effects result from actions at the NMDA receptor complex.

Original language	English (US)
Pages (from-to)	355-358
Number of pages	4
Journal	Brain Research
Volume	526
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(90)91247-E
State	Published - Sep 3 1990
Externally published	Yes

Keywords

Analgesia
Anesthesia
CGS 19755
Excitatory amino acid antagonist
Respiration
Rhesus monkey

ASJC Scopus subject areas

Clinical Neurology
Molecular Biology
General Neuroscience
Developmental Biology

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10.1016/0006-8993(90)91247-E

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title = "Analgesic, anesthetic, and respiratory effects of the competitive N-methyl-d-aspartate (NMDA) antagonist CGS 19755 in rhesus monkeys",

abstract = "The competitive excitatory amino acid antagonist cis-4-phosphonomethyl-2-piperidine-carboxylic acid (CGS 19755) increased the latency for monkeys to remove their tails from warm water (analgesia); larger doses produced ataxia, loss of righting, salivation, and eliminated reactivity to stimulation (anasthesia). CGS 19755 decreased tidal volume and had little effect on frequency of respiration. Although longer lasting, the effects of CGS 19755 were similar to the effects of ketamine, suggesting these effects result from actions at the NMDA receptor complex.",

keywords = "Analgesia, Anesthesia, CGS 19755, Excitatory amino acid antagonist, Respiration, Rhesus monkey",

author = "France, {Charles P.} and Winger, {Gail D.} and Woods, {James H.}",

note = "Funding Information: We would like to thank CIBA-Geigy (Summit, NJ ) for CGS 19755, A. Yung for technical assistance, and L. LaCross and R. McLaughlin for assistance in preparing the manuscript. This research supported by USPHS Grants DA05325 and DA00254.",

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doi = "10.1016/0006-8993(90)91247-E",

language = "English (US)",

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AU - France, Charles P.

AU - Winger, Gail D.

AU - Woods, James H.

N1 - Funding Information: We would like to thank CIBA-Geigy (Summit, NJ ) for CGS 19755, A. Yung for technical assistance, and L. LaCross and R. McLaughlin for assistance in preparing the manuscript. This research supported by USPHS Grants DA05325 and DA00254.

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Y1 - 1990/9/3

N2 - The competitive excitatory amino acid antagonist cis-4-phosphonomethyl-2-piperidine-carboxylic acid (CGS 19755) increased the latency for monkeys to remove their tails from warm water (analgesia); larger doses produced ataxia, loss of righting, salivation, and eliminated reactivity to stimulation (anasthesia). CGS 19755 decreased tidal volume and had little effect on frequency of respiration. Although longer lasting, the effects of CGS 19755 were similar to the effects of ketamine, suggesting these effects result from actions at the NMDA receptor complex.

AB - The competitive excitatory amino acid antagonist cis-4-phosphonomethyl-2-piperidine-carboxylic acid (CGS 19755) increased the latency for monkeys to remove their tails from warm water (analgesia); larger doses produced ataxia, loss of righting, salivation, and eliminated reactivity to stimulation (anasthesia). CGS 19755 decreased tidal volume and had little effect on frequency of respiration. Although longer lasting, the effects of CGS 19755 were similar to the effects of ketamine, suggesting these effects result from actions at the NMDA receptor complex.

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KW - Anesthesia

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KW - Respiration

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Analgesic, anesthetic, and respiratory effects of the competitive N-methyl-d-aspartate (NMDA) antagonist CGS 19755 in rhesus monkeys

Abstract

Keywords

ASJC Scopus subject areas

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