Analgesic, anesthetic, and respiratory effects of the competitive N-methyl-d-aspartate (NMDA) antagonist CGS 19755 in rhesus monkeys

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32 Scopus citations

Abstract

The competitive excitatory amino acid antagonist cis-4-phosphonomethyl-2-piperidine-carboxylic acid (CGS 19755) increased the latency for monkeys to remove their tails from warm water (analgesia); larger doses produced ataxia, loss of righting, salivation, and eliminated reactivity to stimulation (anasthesia). CGS 19755 decreased tidal volume and had little effect on frequency of respiration. Although longer lasting, the effects of CGS 19755 were similar to the effects of ketamine, suggesting these effects result from actions at the NMDA receptor complex.

Original languageEnglish (US)
Pages (from-to)355-358
Number of pages4
JournalBrain Research
Volume526
Issue number2
DOIs
StatePublished - Sep 3 1990
Externally publishedYes

Keywords

  • Analgesia
  • Anesthesia
  • CGS 19755
  • Excitatory amino acid antagonist
  • Respiration
  • Rhesus monkey

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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