An update on complex I assembly: The assembly of players

Rasika S. Vartak, Manpreet Kaur Semwal, Yidong Bai

Research output: Contribution to journalShort survey

15 Scopus citations

Abstract

Defects in Complex I assembly is one of the emerging underlying causes of severe mitochondrial disorders. The assembly of Complex I has been difficult to understand due to its large size, dual genetic control and the number of proteins involved. Mutations in Complex I subunits as well as assembly factors have been reported to hinder its assembly and give rise to a range of mitochondria disorders. In this review, we summarize the recent progress made in understanding the Complex I assembly pathway. In particularly, we focus on the known as well as novel assembly factors and their role in assembly of Complex I and human disease.

Original languageEnglish (US)
Pages (from-to)323-328
Number of pages6
JournalJournal of Bioenergetics and Biomembranes
Volume46
Issue number4
DOIs
StatePublished - Aug 2014

Keywords

  • Assembly
  • Assembly factors
  • Complex I
  • Mitochondrial disorders

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

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