TY - JOUR
T1 - An Overview of the Role of Prophylactic Surgery in the Management of Individuals with a Hereditary Cancer Predisposition
AU - Oseni, Tawakalitu
AU - Jatoi, Ismail
PY - 2008/8
Y1 - 2008/8
N2 - Genetic testing for cancer susceptibility has been implemented widely in recent years, with the hope that it eventually will lead to a reduction in cancer-related mortality. Asymptomatic individuals who have a genetic predisposition for cancer can be identified, and many may benefit from early intervention. Not all of these individuals will develop cancer, however, and the penetrance varies among individuals with different mutations. Surveillance, chemoprevention, and prophylactic surgery are accepted options for managing individuals who have a genetic predisposition for cancer. Yet, there are no randomized prospective trials that have assessed the impact of these interventions specifically in mutation carriers. The decision to undergo prophylactic surgery therefore should be made after all other management options are considered, and the patient is informed of the potential risks and benefits of surgery. This article provides an overview of the role of prophylactic surgery for managing patients who have a genetic predisposition for cancer. It specifically discusses the potential role of surgery in preventing breast, colon, thyroid, and gastric cancers. Additionally, it discusses the types of prophylactic surgical procedures that are performed commonly, and their expanding role in cancer prevention.
AB - Genetic testing for cancer susceptibility has been implemented widely in recent years, with the hope that it eventually will lead to a reduction in cancer-related mortality. Asymptomatic individuals who have a genetic predisposition for cancer can be identified, and many may benefit from early intervention. Not all of these individuals will develop cancer, however, and the penetrance varies among individuals with different mutations. Surveillance, chemoprevention, and prophylactic surgery are accepted options for managing individuals who have a genetic predisposition for cancer. Yet, there are no randomized prospective trials that have assessed the impact of these interventions specifically in mutation carriers. The decision to undergo prophylactic surgery therefore should be made after all other management options are considered, and the patient is informed of the potential risks and benefits of surgery. This article provides an overview of the role of prophylactic surgery for managing patients who have a genetic predisposition for cancer. It specifically discusses the potential role of surgery in preventing breast, colon, thyroid, and gastric cancers. Additionally, it discusses the types of prophylactic surgical procedures that are performed commonly, and their expanding role in cancer prevention.
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U2 - 10.1016/j.suc.2008.04.010
DO - 10.1016/j.suc.2008.04.010
M3 - Review article
C2 - 18672139
AN - SCOPUS:47849111839
SN - 0039-6109
VL - 88
SP - 739
EP - 758
JO - Surgical Clinics of North America
JF - Surgical Clinics of North America
IS - 4
ER -