An overview of the quantitative influence of several risk factors on progression of atherosclerosis in young people in the United States

R. W. Wissler, A. L. Robertson, J. P. Strong, J. F. Cornhill, H. C. McGill, G. T. Malcom, C. A. McMahan, M. C. Oalmann, S. Gay, R. E. Gay, G. Q. Huang, E. J. Miller, D. K. Furuto, M. S. Vail, A. J. Narkates, A. Daoud, A. S. Frank, M. A. Hyer, E. C. McGovern

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

This overview of the National Institutes of Health-supported, multicenter, investigator-initiated study of the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) is designed to summarize the plan, approaches, and the expanding contribution of this unique research program, which is now in its tenth year. It traces for the first time the development, the organization, and the function of the many new features and facets that are being used to yield needed information on the relationships between the classic risk factors and the topography, severity, and the cellular and chemical reactions that influence the development of the early raised plaques. It has also helped establish the factors that influence the progression of the four major types of intermediate raised lesions that grossly are all similar, well delineated fatty plaques. Most of the observations are quantitative. A few glimpses into the unique findings that have been published are presented.

Original languageEnglish (US)
Pages (from-to)S29-S36
JournalAmerican Journal of the Medical Sciences
Volume310
Issue numberSUPPL. 1
DOIs
StatePublished - Jan 1 1995

Keywords

  • Atherosclerosis in youth
  • Atherosclerosis progression
  • Atherosclerosis risk factors

ASJC Scopus subject areas

  • Medicine(all)

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    Wissler, R. W., Robertson, A. L., Strong, J. P., Cornhill, J. F., McGill, H. C., Malcom, G. T., McMahan, C. A., Oalmann, M. C., Gay, S., Gay, R. E., Huang, G. Q., Miller, E. J., Furuto, D. K., Vail, M. S., Narkates, A. J., Daoud, A., Frank, A. S., Hyer, M. A., & McGovern, E. C. (1995). An overview of the quantitative influence of several risk factors on progression of atherosclerosis in young people in the United States. American Journal of the Medical Sciences, 310(SUPPL. 1), S29-S36. https://doi.org/10.1097/00000441-199512000-00006