An overview of Kampo medicine: Toki‐Shakuyaku‐San (TJ‐23)

Nobuyoshi Hagino

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


Toki‐Shakuyaku‐San (TJ‐23) is one of the most popular Kampo medicines in Japan and it is used for the treatment of ovarian dysfunction and menopausal syndrome in women. We have demonstrated that TJ‐23 has a neuroendocrine effect and facilitates hypothalamic‐controlled pituitary and ovarian functions. Furthermore, we have also observed that TJ‐23 has a stimulatory effect for the synthesis and release of neurotransmitters, such as acetylcholine, dopamine and norepinephrine by activating related enzymes in the brain. Furthermore, TJ‐23 increases the synthesis of nicotine acetylcholine receptors in the brain. Administration of TJ‐23 facilitates memory related behaviour in experimental animals. In addition TJ‐23 has a neuroprotective effect for neuron death. The clinical application of TJ‐23 in open trials for patients with Alzheimer's disease improved their memory related behaviour and intellectual function. Moreover, treatment with TJ‐23 provides motivation for daily life in Alzheimer‐type patients with dementia. Basic research and clinical trials suggest strongly that TJ‐23 has a therapeutic efficacy for the treatment of dementia of the Alzheimer type.

Original languageEnglish (US)
Pages (from-to)391-394
Number of pages4
JournalPhytotherapy Research
Issue number6
StatePublished - 1993
Externally publishedYes


  • Alzheimer's disease
  • biochemical
  • pharmacological
  • therapeutic review
  • Toki‐Shakuyaku‐San (TJ‐23)

ASJC Scopus subject areas

  • Pharmacology


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