An overview of epigenetics and chemoprevention

Yi Wen Huang, Chieh Ti Kuo, Kristen Stoner, Tim H.Y. Huang, Li Shu Wang

Research output: Contribution to journalReview article

45 Scopus citations

Abstract

It is now appreciated that both genetic alteration, e.g. mutations, and aberrant epigenetic changes, e.g. DNA methylation, cause cancer. Epigenetic dysregulation is potentially reversible which makes it attractive as targets for cancer prevention. Synthetic drugs targeting enzymes, e.g. DNA methyltransferase and histone deacetylase, that regulate epigenetic patterns are active in clinical settings. In addition, dietary factors have been suggested to have potential to reverse aberrant epigenetic patterns. Uncovering the human epigenome can lead us to better understand the dynamics of DNA methylation in disease progression which can further assist in cancer prevention.

Original languageEnglish (US)
Pages (from-to)2129-2136
Number of pages8
JournalFEBS Letters
Volume585
Issue number13
DOIs
StatePublished - Jul 7 2011
Externally publishedYes

Keywords

  • Cancer prevention
  • DNA methylation
  • Epigenome

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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  • Cite this

    Huang, Y. W., Kuo, C. T., Stoner, K., Huang, T. H. Y., & Wang, L. S. (2011). An overview of epigenetics and chemoprevention. FEBS Letters, 585(13), 2129-2136. https://doi.org/10.1016/j.febslet.2010.11.002