An overview of epigenetics and chemoprevention

Yi Wen Huang, Chieh Ti Kuo, Kristen Stoner, Tim H.Y. Huang, Li Shu Wang

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations


It is now appreciated that both genetic alteration, e.g. mutations, and aberrant epigenetic changes, e.g. DNA methylation, cause cancer. Epigenetic dysregulation is potentially reversible which makes it attractive as targets for cancer prevention. Synthetic drugs targeting enzymes, e.g. DNA methyltransferase and histone deacetylase, that regulate epigenetic patterns are active in clinical settings. In addition, dietary factors have been suggested to have potential to reverse aberrant epigenetic patterns. Uncovering the human epigenome can lead us to better understand the dynamics of DNA methylation in disease progression which can further assist in cancer prevention.

Original languageEnglish (US)
Pages (from-to)2129-2136
Number of pages8
JournalFEBS Letters
Issue number13
StatePublished - Jul 7 2011
Externally publishedYes


  • Cancer prevention
  • DNA methylation
  • Epigenome

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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