An Overview of Autologous Skin Grafts and Advanced Biologics for the Diabetic Foot

A wide array of reconstructive options exists for soft tissue coverage of diabetic foot wounds; however, each case depends on the patient's medical comorbidities, wound type, anatomy of the affected site, and level of contamination. Although autologous skin grafts have traditionally played a pivotal role in the coverage of diabetic wounds, several advanced biological skin substitutes have become available, providing surgeons with additional choices in the management of these challenging wounds. This article reviews these surgical modalities by presenting indications for every option and clinical scenario that may benefit from their combined use.