An original flow diversion device for the treatment of intracranial aneurysms: Evaluation in the rabbit elastase-induced model

Chander Sadasivan, Liliana Cesar, Jaehoon Seong, Audrey Rakian, Qing Hao, Fermin O. Tio, Ajay K. Wakhloo, Baruch B. Lieber

Research output: Contribution to journalArticlepeer-review

170 Scopus citations

Abstract

Background and Purpose - The potential for successful treatment of intracranial aneurysms by flow diversion is gradually being recognized in the clinical setting; however, the devices currently available (stents) are not designed for flow diversion. We evaluate the long-term response of an appropriately designed flow diversion device in producing thrombotic occlusion of experimental aneurysms. Methods - Three different configurations of an original flow diversion device were implanted across thirty elastase-induced aneurysm models in rabbits. Ten animals per device configuration were followed-up for 3 weeks (n=3), 3 months (n=3), or 6 months (n=4), and tissue explanted postsacrifice was sent for histology. The temporal variation in angiographic contrast intensity within each aneurysm was fitted with a mathematical model to quantify the alteration in local hemodynamics caused by the implanted device. A predictive index, called the washout coefficient, was constructed to estimate long-term aneurysm occlusion probabilities immediately after treatment with any flow diversion device. Results - The device with a porosity of 70% and pore density of 18 pores/mm2 performed better at occluding aneurysms than devices with 70% porosity, 12 pores/mm2 and 65% porosity, 14 pores/mm2. A value of the washout coefficient less than 30 predicted greater than 97% angiographic aneurysm occlusion over a period of 6 months with a sensitivity of 73% and specificity of 82%. Conclusions - The flow diversion devices effected successful and stable aneurysm occlusion. Pore density, rather than porosity, may be the critical factor modulating efficacy of such devices.

Original languageEnglish (US)
Pages (from-to)952-958
Number of pages7
JournalStroke
Volume40
Issue number3
DOIs
StatePublished - Mar 2009

Keywords

  • Histology
  • Scanning electron microscopy
  • Side-branch patency
  • Stents
  • Washout coefficient

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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