@article{ce4e67c83fde4090893eff8d993fe179,
title = "An optimized microarray platform for assaying genomic variation in Plasmodium falciparum field populations",
abstract = "We present an optimized probe design for copy number variation (CNV) and SNP genotyping in the Plasmodium falciparum genome. We demonstrate that variable length and isothermal probes are superior to static length probes. We show that sample preparation and hybridization conditions mitigate the effects of host DNA contamination in field samples. The microarray and workflow presented can be used to identify CNVs and SNPs with 95% accuracy in a single hybridization, in field samples containing up to 92% human DNA contamination.",
author = "Tan, {John C.} and Miller, {Becky A.} and Asako Tan and Patel, {Jigar J.} and Cheeseman, {Ian H.} and Anderson, {Tim J.C.} and Magnus Manske and Gareth Maslen and Kwiatkowski, {Dominic P.} and Ferdig, {Michael T.}",
note = "Funding Information: This work was supported by the National Institutes of Health (AI072517, AI075145 to MTF; AI075145 to TJA). The molecular work at the Southwest Foundation for Biomedical Research was conducted in facilities constructed with support from the National Center for Research Resources, National Institutes of Health (RR013556). We are grateful to F Nosten and the Shoklo Malaria Research Unit for providing samples. We thank L Checkley, S Nair, S Al-Saai, and the Notre Dame Genomics Core Facility for excellent technical support.",
year = "2011",
month = apr,
day = "8",
doi = "10.1186/gb-2011-12-4-r35",
language = "English (US)",
volume = "12",
journal = "Genome Biology",
issn = "1474-7596",
publisher = "BioMed Central",
number = "4",
}