An oncofetal 60-kilodalton protein in the plasma of tumor-bearing and carcinogen-treated rats

Zbigniew Walaszek, Margaret Hanausek-Walaszek, Dorothy E. Schumm, Thomas E. Webb

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

A Mr 60,000 protein, detected by its ability to induce the release of RNA from isolated nuclei, is present in the plasma of tumor-bearing and carcinogen-treated rats, together with low amounts of 2 messenger RNA transport proteins identified earlier in normal cells. The Mr 60,000 protein has been identified in tumor cell cytoplasm and in amniotic fluid, but does not appear to cross the placental barrier. Significant amounts of the Mr 60,000 oncofetal protein appear in the plasma of carcinogen-treated rats within a few weeks of treatment. It may be the fetal form of the adult messenger RNA transport proteins.

Original languageEnglish (US)
Pages (from-to)277-282
Number of pages6
JournalCancer Letters
Volume20
Issue number3
DOIs
StatePublished - Oct 1983
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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