An investigation of the 5-HT2C receptor gene as a migraine candidate gene

Matthew P. Johnson, Rod A. Lea, Robert P. Curtain, John C. MacMillan, Lyn R. Griffiths

    Research output: Contribution to journalArticlepeer-review

    25 Scopus citations

    Abstract

    Migraine is a common complex disorder, currently classified into two main subtypes, migraine with aura (MA) and migraine without aura (MO). The strong preponderance of females to males suggests an X-linked genetic component. Recent studies have identified an X chromosomal susceptibility region (Xq24-q28) in two typical migraine pedigrees. This region harbours a potential candidate gene for the disorder, the serotonin receptor 2C (5-HT2C) gene. This study involved a linkage and association approach to investigate two single nucleotide variants in the 5-HT2C gene. In addition, exonic coding regions of the 5-HT2C gene were also sequenced for mutations in X-linked migraine pedigrees. Results of this study did not detect any linkage or association, and no disease causing mutations were identified. Hence, results for this study do not support a significant role of the 5-HT 2C gene in migraine predisposition.

    Original languageEnglish (US)
    Pages (from-to)86-89
    Number of pages4
    JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
    Volume117 B
    Issue number1
    StatePublished - Feb 15 2003

    Keywords

    • 5-HT
    • Association
    • Linkage
    • Migraine

    ASJC Scopus subject areas

    • Genetics(clinical)
    • Psychiatry and Mental health
    • Cellular and Molecular Neuroscience

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