An investigation of the 5-HT2C receptor gene as a migraine candidate gene

Matthew P. Johnson; Rod A. Lea; Robert P. Curtain; John C. MacMillan; Lyn R. Griffiths

An investigation of the 5-HT_2C receptor gene as a migraine candidate gene

Matthew P. Johnson, Rod A. Lea, Robert P. Curtain, John C. MacMillan, Lyn R. Griffiths

Research output: Contribution to journal › Article › peer-review

Abstract

Migraine is a common complex disorder, currently classified into two main subtypes, migraine with aura (MA) and migraine without aura (MO). The strong preponderance of females to males suggests an X-linked genetic component. Recent studies have identified an X chromosomal susceptibility region (Xq24-q28) in two typical migraine pedigrees. This region harbours a potential candidate gene for the disorder, the serotonin receptor 2C (5-HT_2C) gene. This study involved a linkage and association approach to investigate two single nucleotide variants in the 5-HT_2C gene. In addition, exonic coding regions of the 5-HT_2C gene were also sequenced for mutations in X-linked migraine pedigrees. Results of this study did not detect any linkage or association, and no disease causing mutations were identified. Hence, results for this study do not support a significant role of the 5-HT _2C gene in migraine predisposition.

Original language	English (US)
Pages (from-to)	86-89
Number of pages	4
Journal	American Journal of Medical Genetics - Neuropsychiatric Genetics
Volume	117 B
Issue number	1
State	Published - Feb 15 2003

Keywords

5-HT
Association
Linkage
Migraine

ASJC Scopus subject areas

Genetics(clinical)
Psychiatry and Mental health
Cellular and Molecular Neuroscience

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title = "An investigation of the 5-HT2C receptor gene as a migraine candidate gene",

abstract = "Migraine is a common complex disorder, currently classified into two main subtypes, migraine with aura (MA) and migraine without aura (MO). The strong preponderance of females to males suggests an X-linked genetic component. Recent studies have identified an X chromosomal susceptibility region (Xq24-q28) in two typical migraine pedigrees. This region harbours a potential candidate gene for the disorder, the serotonin receptor 2C (5-HT2C) gene. This study involved a linkage and association approach to investigate two single nucleotide variants in the 5-HT2C gene. In addition, exonic coding regions of the 5-HT2C gene were also sequenced for mutations in X-linked migraine pedigrees. Results of this study did not detect any linkage or association, and no disease causing mutations were identified. Hence, results for this study do not support a significant role of the 5-HT 2C gene in migraine predisposition.",

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AU - Johnson, Matthew P.

AU - Lea, Rod A.

AU - Curtain, Robert P.

AU - MacMillan, John C.

AU - Griffiths, Lyn R.

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AB - Migraine is a common complex disorder, currently classified into two main subtypes, migraine with aura (MA) and migraine without aura (MO). The strong preponderance of females to males suggests an X-linked genetic component. Recent studies have identified an X chromosomal susceptibility region (Xq24-q28) in two typical migraine pedigrees. This region harbours a potential candidate gene for the disorder, the serotonin receptor 2C (5-HT2C) gene. This study involved a linkage and association approach to investigate two single nucleotide variants in the 5-HT2C gene. In addition, exonic coding regions of the 5-HT2C gene were also sequenced for mutations in X-linked migraine pedigrees. Results of this study did not detect any linkage or association, and no disease causing mutations were identified. Hence, results for this study do not support a significant role of the 5-HT 2C gene in migraine predisposition.

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