An Introduction to the Callithrix Genus and Overview of Recent Advances in Marmoset Research

Joanna Malukiewicz, Vanner Boere, Maria Adelia Borstelmann De Oliveira, Mirela D'arc, Jessica V.A. Ferreira, Jeffrey French, Genevieve Housman, Claudia Igayara De Souza, Leandro Jerusalinsky, Fabiano R. De Melo, Monica M. Valenca-Montenegro, Silvia Bahadian Moreira, Ita De Oliveira E. Silva, Felipe Santos Pacheco, Jeffrey Rogers, Alcides Pissinatti, Ricardo C.H. Del Rosario, Corinna Ross, Carlos R. Ruiz-Miranda, Luiz C.M. PereiraNicola Schiel, Fernanda De Fatima Rodrigues Da Silva, Antonio Souto, Vedrana Šlipogor, Suzette Tardif

Research output: Contribution to journalReview articlepeer-review

Abstract

We provide here a current overview of marmoset (Callithrix) evolution, hybridization, species biology, basic/biomedical research, and conservation initiatives. Composed of 2 subgroups, the aurita group (C aurita and C flaviceps) and the jacchus group (C geoffroyi, C jacchus, C kuhlii, and C penicillata), this relatively young primate radiation is endemic to the Brazilian Cerrado, Caatinga, and Atlantic Forest biomes. Significant impacts on Callithrix within these biomes resulting from anthropogenic activity include (1) population declines, particularly for the aurita group; (2) widespread geographic displacement, biological invasions, and range expansions of C jacchus and C penicillata; (3) anthropogenic hybridization; and (4) epizootic Yellow Fever and Zika viral outbreaks. A number of Brazilian legal and conservation initiatives are now in place to protect the threatened aurita group and increase research about them. Due to their small size and rapid life history, marmosets are prized biomedical models. As a result, there are increasingly sophisticated genomic Callithrix resources available and burgeoning marmoset functional, immuno-, and epigenomic research. In both the laboratory and the wild, marmosets have given us insight into cognition, social group dynamics, human disease, and pregnancy. Callithrix jacchus and C penicillata are emerging neotropical primate models for arbovirus disease, including Dengue and Zika. Wild marmoset populations are helping us understand sylvatic transmission and human spillover of Zika and Yellow Fever viruses. All of these factors are positioning marmosets as preeminent models to facilitate understanding of facets of evolution, hybridization, conservation, human disease, and emerging infectious diseases.

Original languageEnglish (US)
Pages (from-to)110-138
Number of pages29
JournalILAR Journal
Volume61
Issue number2-3
DOIs
StatePublished - 2020

Keywords

  • Brazil
  • arbovirus
  • biological invasion
  • biomedical
  • callitrichid
  • conservation
  • endangered
  • hybridization
  • neotropical
  • pathogen

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Biochemistry, Genetics and Molecular Biology(all)

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