Abstract
Obesity is a growing epidemic all over the world that by virtue of inducation of a chronic, low-grade, and systemic inflammation leads to an increased risk of a number of diseases, including cancer. IL-6 an important cytokine in the increased risk to cancer in obese patients mainly because of its pro-inflammatory activitiy. Some data suggest that IL-6 might increase the risk of certain cancers such as those that originate from breast, liver, prostate, colon, and esophagus. A better understanding of the regulation and role of IL-6 in obesity-associated cancer is required to develop effective therapeutic approaches. Sagar Ghosh was supported in the writing of this article by a grant from San Antonio Area Foundation, San Antonio, Texas, United States of America.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 461-478 |
| Number of pages | 18 |
| Journal | Frontiers in Bioscience - Elite |
| Volume | 5 E |
| Issue number | 2 |
| State | Published - Jan 1 2013 |
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Keywords
- Adipose stromal cells
- Cancer
- IL-6
- Obesity
- Review
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
- Medicine(all)
Cite this
An IL-6 link between obesity and cancer. / Ghosh, Sagar; Ashcraft, Keith.
In: Frontiers in Bioscience - Elite, Vol. 5 E, No. 2, 01.01.2013, p. 461-478.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - An IL-6 link between obesity and cancer
AU - Ghosh, Sagar
AU - Ashcraft, Keith
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Obesity is a growing epidemic all over the world that by virtue of inducation of a chronic, low-grade, and systemic inflammation leads to an increased risk of a number of diseases, including cancer. IL-6 an important cytokine in the increased risk to cancer in obese patients mainly because of its pro-inflammatory activitiy. Some data suggest that IL-6 might increase the risk of certain cancers such as those that originate from breast, liver, prostate, colon, and esophagus. A better understanding of the regulation and role of IL-6 in obesity-associated cancer is required to develop effective therapeutic approaches. Sagar Ghosh was supported in the writing of this article by a grant from San Antonio Area Foundation, San Antonio, Texas, United States of America.
AB - Obesity is a growing epidemic all over the world that by virtue of inducation of a chronic, low-grade, and systemic inflammation leads to an increased risk of a number of diseases, including cancer. IL-6 an important cytokine in the increased risk to cancer in obese patients mainly because of its pro-inflammatory activitiy. Some data suggest that IL-6 might increase the risk of certain cancers such as those that originate from breast, liver, prostate, colon, and esophagus. A better understanding of the regulation and role of IL-6 in obesity-associated cancer is required to develop effective therapeutic approaches. Sagar Ghosh was supported in the writing of this article by a grant from San Antonio Area Foundation, San Antonio, Texas, United States of America.
KW - Adipose stromal cells
KW - Cancer
KW - IL-6
KW - Obesity
KW - Review
UR - http://www.scopus.com/inward/record.url?scp=84878475744&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878475744&partnerID=8YFLogxK
M3 - Article
C2 - 23277002
AN - SCOPUS:84878475744
VL - 5 E
SP - 461
EP - 478
JO - Frontiers in Bioscience - Elite
JF - Frontiers in Bioscience - Elite
SN - 1945-0494
IS - 2
ER -