An IL-6 link between obesity and cancer

Sagar Ghosh, Keith Ashcraft

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Obesity is a growing epidemic all over the world that by virtue of inducation of a chronic, low-grade, and systemic inflammation leads to an increased risk of a number of diseases, including cancer. IL-6 an important cytokine in the increased risk to cancer in obese patients mainly because of its pro-inflammatory activitiy. Some data suggest that IL-6 might increase the risk of certain cancers such as those that originate from breast, liver, prostate, colon, and esophagus. A better understanding of the regulation and role of IL-6 in obesity-associated cancer is required to develop effective therapeutic approaches. Sagar Ghosh was supported in the writing of this article by a grant from San Antonio Area Foundation, San Antonio, Texas, United States of America.

Original languageEnglish (US)
Pages (from-to)461-478
Number of pages18
JournalFrontiers in Bioscience - Elite
Volume5 E
Issue number2
StatePublished - Jan 1 2013

Fingerprint

Interleukin-6
Obesity
Neoplasms
Liver
Organized Financing
Cytokines
Esophagus
Prostate
Colon
Breast
Inflammation
Therapeutics

Keywords

  • Adipose stromal cells
  • Cancer
  • IL-6
  • Obesity
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Ghosh, S., & Ashcraft, K. (2013). An IL-6 link between obesity and cancer. Frontiers in Bioscience - Elite, 5 E(2), 461-478.

An IL-6 link between obesity and cancer. / Ghosh, Sagar; Ashcraft, Keith.

In: Frontiers in Bioscience - Elite, Vol. 5 E, No. 2, 01.01.2013, p. 461-478.

Research output: Contribution to journalArticle

Ghosh, S & Ashcraft, K 2013, 'An IL-6 link between obesity and cancer', Frontiers in Bioscience - Elite, vol. 5 E, no. 2, pp. 461-478.
Ghosh S, Ashcraft K. An IL-6 link between obesity and cancer. Frontiers in Bioscience - Elite. 2013 Jan 1;5 E(2):461-478.
Ghosh, Sagar ; Ashcraft, Keith. / An IL-6 link between obesity and cancer. In: Frontiers in Bioscience - Elite. 2013 ; Vol. 5 E, No. 2. pp. 461-478.
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