Abstract
Obesity is a growing epidemic all over the world that by virtue of inducation of a chronic, low-grade, and systemic inflammation leads to an increased risk of a number of diseases, including cancer. IL-6 an important cytokine in the increased risk to cancer in obese patients mainly because of its pro-inflammatory activitiy. Some data suggest that IL-6 might increase the risk of certain cancers such as those that originate from breast, liver, prostate, colon, and esophagus. A better understanding of the regulation and role of IL-6 in obesity-associated cancer is required to develop effective therapeutic approaches. Sagar Ghosh was supported in the writing of this article by a grant from San Antonio Area Foundation, San Antonio, Texas, United States of America.
Original language | English (US) |
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Pages (from-to) | 461-478 |
Number of pages | 18 |
Journal | Frontiers in Bioscience - Elite |
Volume | 5 E |
Issue number | 2 |
DOIs | |
State | Published - Jan 1 2013 |
Keywords
- Adipose stromal cells
- Cancer
- IL-6
- Obesity
- Review
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)