An IL-6 link between obesity and cancer

Sagar Ghosh, Keith Ashcraft

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Obesity is a growing epidemic all over the world that by virtue of inducation of a chronic, low-grade, and systemic inflammation leads to an increased risk of a number of diseases, including cancer. IL-6 an important cytokine in the increased risk to cancer in obese patients mainly because of its pro-inflammatory activitiy. Some data suggest that IL-6 might increase the risk of certain cancers such as those that originate from breast, liver, prostate, colon, and esophagus. A better understanding of the regulation and role of IL-6 in obesity-associated cancer is required to develop effective therapeutic approaches. Sagar Ghosh was supported in the writing of this article by a grant from San Antonio Area Foundation, San Antonio, Texas, United States of America.

Original languageEnglish (US)
Pages (from-to)461-478
Number of pages18
JournalFrontiers in Bioscience - Elite
Volume5 E
Issue number2
DOIs
StatePublished - Jan 1 2013

Keywords

  • Adipose stromal cells
  • Cancer
  • IL-6
  • Obesity
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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