An efficient and practical radiosynthesis of [11C]temozolomide

Christian K. Moseley, Stephen M. Carlin, Ramesh Neelamegam, Jacob M. Hooker

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Temozolomide (TMZ) is a prodrug for an alkylating agent used for the treatment of malignant brain tumors. A positron emitting version, [ 11C]TMZ, has been utilized to help elucidate the mechanism and biodistribution of TMZ. Challenges in [11C]TMZ synthesis and reformulation make it difficult for routine production. A highly reproducible one-pot radiosynthesis of [11C]TMZ with a radiochemical yield of 17 ± 5% and ≥97% radiochemical purity is reported.

Original languageEnglish (US)
Pages (from-to)5872-5875
Number of pages4
JournalOrganic Letters
Volume14
Issue number23
DOIs
StatePublished - Dec 7 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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