An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians

Robert L. Hanson, Margaret G. Ehm, David J. Pettitt, Michal Prochazka, D. Bruce Thompson, David Timberlake, Tatiana Foroud, Sayuko Kobes, Leslie Baier, Daniel K. Burns, Laura Almasy, John Blangero, W. Timothy Garvey, Peter H. Bennett, William C. Knowler

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    Abstract

    Genetic factors influence the development of type II diabetes mellitus, but genetic loci for the most common forms of diabetes have not been identified. A genomic scan was conducted to identify loci linked to diabetes and body-mass index (BMI) in Pima Indians, a Native American population with a high prevalence of type II diabetes. Among 264 nuclear families containing 966 siblings, 516 autosomal markers with a median distance between adjacent markers of 6.4 cM were genotyped. Variance-components methods were used to test for linkage with an age-adjusted diabetes score and with BMI. In multipoint analyses, the strongest evidence for linkage with age-adjusted diabetes (LOD = 1.7) was on chromosome 11q, in the region that was also linked most strongly with BMI (LOD = 3.6). Bivariate linkage analyses strongly rejected both the null hypothesis of no linkage with either trait and the null hypothesis of no contribution of the locus to the covariation among the two traits. Sib-pair analyses suggest additional potential diabetes-susceptibility loci on chromosomes 1q and 7q.

    Original languageEnglish (US)
    Pages (from-to)1130-1138
    Number of pages9
    JournalAmerican Journal of Human Genetics
    Volume63
    Issue number4
    DOIs
    StatePublished - Jan 1 1998

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    ASJC Scopus subject areas

    • Genetics
    • Genetics(clinical)

    Cite this

    Hanson, R. L., Ehm, M. G., Pettitt, D. J., Prochazka, M., Thompson, D. B., Timberlake, D., Foroud, T., Kobes, S., Baier, L., Burns, D. K., Almasy, L., Blangero, J., Garvey, W. T., Bennett, P. H., & Knowler, W. C. (1998). An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians. American Journal of Human Genetics, 63(4), 1130-1138. https://doi.org/10.1086/302061