An Application of a Service-oriented System to Support ArrayAnnotation in Custom Chip Design for Epigenomic Analysis

Junghee Han; Dustin Potter; Tahsin Kurc; Greg Singer; Pearlly S. Yan; Sun Hao; Shannon Hastings; Stephen Langella; Scott Oster; Ramana V. Davuluri; Tim H.M. Huang; Joel H. Saltz

doi:10.4137/117693510800600005

An Application of a Service-oriented System to Support ArrayAnnotation in Custom Chip Design for Epigenomic Analysis

Junghee Han, Dustin Potter, Tahsin Kurc, Greg Singer, Pearlly S. Yan, Sun Hao, Shannon Hastings, Stephen Langella, Scott Oster, Ramana V. Davuluri, Tim H.M. Huang, Joel H. Saltz

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We present the implementation of an application using caGrid, which is the service-oriented Grid software infrastructure of the NCI cancer Biomedical Informatics Grid (caBIG^™), to support design and analysis of custom microarray experiments in the study of epigenetic alterations in cancer. The design and execution of these experiments requires synthesis of information from multiple data types and datasets. In our implementation, each data source is implemented as a caGrid Data Service, and analytical resources are wrapped as caGrid Analytical Services. This service-based implementation has several advantages. A backend resource can be modified or upgraded, without needing to change other components in the application. A remote resource can be added easily, since resources are not required to be collected in a centralized infrastructure.

Original language	English (US)
Journal	Cancer Informatics
Volume	6
DOIs	https://doi.org/10.4137/117693510800600005
State	Published - 2008
Externally published	Yes

Keywords

caBIG and caGrid
data integration
epigenetic studies
grid computing
service oriented architectures

ASJC Scopus subject areas

Oncology
Cancer Research

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10.4137/117693510800600005

Cite this

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title = "An Application of a Service-oriented System to Support ArrayAnnotation in Custom Chip Design for Epigenomic Analysis",

abstract = "We present the implementation of an application using caGrid, which is the service-oriented Grid software infrastructure of the NCI cancer Biomedical Informatics Grid (caBIG{\texttrademark}), to support design and analysis of custom microarray experiments in the study of epigenetic alterations in cancer. The design and execution of these experiments requires synthesis of information from multiple data types and datasets. In our implementation, each data source is implemented as a caGrid Data Service, and analytical resources are wrapped as caGrid Analytical Services. This service-based implementation has several advantages. A backend resource can be modified or upgraded, without needing to change other components in the application. A remote resource can be added easily, since resources are not required to be collected in a centralized infrastructure.",

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author = "Junghee Han and Dustin Potter and Tahsin Kurc and Greg Singer and Yan, {Pearlly S.} and Sun Hao and Shannon Hastings and Stephen Langella and Scott Oster and Davuluri, {Ramana V.} and Huang, {Tim H.M.} and Saltz, {Joel H.}",

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doi = "10.4137/117693510800600005",

language = "English (US)",

volume = "6",

journal = "Cancer Informatics",

issn = "1176-9351",

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AU - Han, Junghee

AU - Potter, Dustin

AU - Kurc, Tahsin

AU - Singer, Greg

AU - Yan, Pearlly S.

AU - Hao, Sun

AU - Hastings, Shannon

AU - Langella, Stephen

AU - Oster, Scott

AU - Davuluri, Ramana V.

AU - Huang, Tim H.M.

AU - Saltz, Joel H.

PY - 2008

Y1 - 2008

N2 - We present the implementation of an application using caGrid, which is the service-oriented Grid software infrastructure of the NCI cancer Biomedical Informatics Grid (caBIG™), to support design and analysis of custom microarray experiments in the study of epigenetic alterations in cancer. The design and execution of these experiments requires synthesis of information from multiple data types and datasets. In our implementation, each data source is implemented as a caGrid Data Service, and analytical resources are wrapped as caGrid Analytical Services. This service-based implementation has several advantages. A backend resource can be modified or upgraded, without needing to change other components in the application. A remote resource can be added easily, since resources are not required to be collected in a centralized infrastructure.

AB - We present the implementation of an application using caGrid, which is the service-oriented Grid software infrastructure of the NCI cancer Biomedical Informatics Grid (caBIG™), to support design and analysis of custom microarray experiments in the study of epigenetic alterations in cancer. The design and execution of these experiments requires synthesis of information from multiple data types and datasets. In our implementation, each data source is implemented as a caGrid Data Service, and analytical resources are wrapped as caGrid Analytical Services. This service-based implementation has several advantages. A backend resource can be modified or upgraded, without needing to change other components in the application. A remote resource can be added easily, since resources are not required to be collected in a centralized infrastructure.

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KW - data integration

KW - epigenetic studies

KW - grid computing

KW - service oriented architectures

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An Application of a Service-oriented System to Support ArrayAnnotation in Custom Chip Design for Epigenomic Analysis

Abstract

Keywords

ASJC Scopus subject areas

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