An acid-catalyzed 1,4-addition isocyanide-based multicomponent reaction in neat water

Jie Lei, Jie Lei, Yong Li, Yong Li, Jia Xu, Dian Yong Tang, Jing Wei Shao, Hong Yu Li, Zhong Zhu Chen, Zhi Gang Xu

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

A green 1,4-addition isocyanide-based three-component reaction was developed to synthesize chromanones via a facile, mild, and efficient one-pot protocol without a metal catalyst. The 1,4-addition of isocyanides occurred at the C-2 position of chromones instead of the Schiff base in neat water. We found that the hydrogen bond can dictate the stereo-outcome of olefins, providing an effective method for the diastereomer-selective synthesis of this type of chromanone. The novel green synthetic protocol allowed the quick synthesis of complex chromanones in an environmentally friendly manner.

Original languageEnglish (US)
Pages (from-to)3716-3720
Number of pages5
JournalGreen Chemistry
Volume22
Issue number12
DOIs
StatePublished - Jun 21 2020
Externally publishedYes

ASJC Scopus subject areas

  • Environmental Chemistry
  • Pollution

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