Abstract
A green 1,4-addition isocyanide-based three-component reaction was developed to synthesize chromanones via a facile, mild, and efficient one-pot protocol without a metal catalyst. The 1,4-addition of isocyanides occurred at the C-2 position of chromones instead of the Schiff base in neat water. We found that the hydrogen bond can dictate the stereo-outcome of olefins, providing an effective method for the diastereomer-selective synthesis of this type of chromanone. The novel green synthetic protocol allowed the quick synthesis of complex chromanones in an environmentally friendly manner.
Original language | English (US) |
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Pages (from-to) | 3716-3720 |
Number of pages | 5 |
Journal | Green Chemistry |
Volume | 22 |
Issue number | 12 |
DOIs | |
State | Published - Jun 21 2020 |
Externally published | Yes |
ASJC Scopus subject areas
- Environmental Chemistry
- Pollution