TY - JOUR
T1 - Amygdala reactivity predicts adolescent antisocial behavior but not callous-unemotional traits
AU - Dotterer, Hailey L.
AU - Hyde, Luke W.
AU - Swartz, Johnna R.
AU - Hariri, Ahmad R.
AU - Williamson, Douglas E.
N1 - Funding Information:
The work was supported by grants to the fourth author by the National Institute on Drug Abuse [R01DA033369, R01DA031579, and R01AG049789]; grants to the fifth author by the National Institute of Alcohol Abuse and Alcoholism (R01AA016274) and the Dielmann Family; and grants to the third author by the National Institute on Drug Abuse (P30DA023026) and the National Institute on Aging (R01AG049789), and Prop. 63, the Mental Health Services Act and the Behavioral Health Center of Excellence at UC Davis.
Publisher Copyright:
© 2017 The Authors
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Recent neuroimaging studies have suggested divergent relationships between antisocial behavior (AB) and callous-unemotional (CU) traits and amygdala reactivity to fearful and angry facial expressions in adolescents. However, little work has examined if these findings extend to dimensional measures of behavior in ethnically diverse, non-clinical samples, or if participant sex, ethnicity, pubertal stage, and age moderate associations. We examined links between amygdala reactivity and dimensions of AB and CU traits in 220 Hispanic and non-Hispanic Caucasian adolescents (age 11–15; 49.5% female; 38.2% Hispanic), half of whom had a family history for depression and thus were at relatively elevated risk for late starting, emotionally dysregulated AB. We found that AB was significantly related to increased right amygdala reactivity to angry facial expressions independent of sex, ethnicity, pubertal stage, age, and familial risk status for depression. CU traits were not related to fear- or anger-related amygdala reactivity. The present study further demonstrates that AB is related to increased amygdala reactivity to interpersonal threat cues in adolescents, and that this relationship generalizes across sex, ethnicity, pubertal stage, age, and familial risk status for depression.
AB - Recent neuroimaging studies have suggested divergent relationships between antisocial behavior (AB) and callous-unemotional (CU) traits and amygdala reactivity to fearful and angry facial expressions in adolescents. However, little work has examined if these findings extend to dimensional measures of behavior in ethnically diverse, non-clinical samples, or if participant sex, ethnicity, pubertal stage, and age moderate associations. We examined links between amygdala reactivity and dimensions of AB and CU traits in 220 Hispanic and non-Hispanic Caucasian adolescents (age 11–15; 49.5% female; 38.2% Hispanic), half of whom had a family history for depression and thus were at relatively elevated risk for late starting, emotionally dysregulated AB. We found that AB was significantly related to increased right amygdala reactivity to angry facial expressions independent of sex, ethnicity, pubertal stage, age, and familial risk status for depression. CU traits were not related to fear- or anger-related amygdala reactivity. The present study further demonstrates that AB is related to increased amygdala reactivity to interpersonal threat cues in adolescents, and that this relationship generalizes across sex, ethnicity, pubertal stage, age, and familial risk status for depression.
KW - Amygdala
KW - Antisocial behavior
KW - Callous-unemotional traits
KW - Threat
KW - fMRI
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U2 - 10.1016/j.dcn.2017.02.008
DO - 10.1016/j.dcn.2017.02.008
M3 - Article
C2 - 28279916
AN - SCOPUS:85014495935
VL - 24
SP - 84
EP - 92
JO - Developmental Cognitive Neuroscience
JF - Developmental Cognitive Neuroscience
SN - 1878-9293
ER -