Amygdala and hippocampal volumes in Turner syndrome: A high-resolution MRI study of X-monosomy

Shelli R. Kesler, Amy Garrett, Bruce Bender, Jerome Yankowitz, She Min Zeng, Allan L. Reiss

Research output: Contribution to journalArticlepeer-review

81 Scopus citations


Turner syndrome (TS) results from partial or complete X-monosomy and is characterized by deficits in visuospatial functioning as well as social cognition and memory. Neuroimaging studies have demonstrated volumetric differences in the parietal region of females with TS compared to controls. The present study examined amygdala and hippocampus morphology in an attempt to further understand the neural correlates of psychosocial and memory functioning in TS. Thirty females with TS age 7.6-33.3 years (mean = 14.7 ± 6.4) and 29 age-matched controls (mean age = 14.8 ± 5.9; range = 6.4-32.7) were scanned using high resolution MRI. Volumetric analyses of the MRI scans included whole brain segmentation and manual delineation of the amygdala and hippocampus. Compared to controls, participants with TS demonstrated significantly larger left amygdala gray matter volumes, irrespective of total cerebral tissue and age. Participants with TS also showed disproportionately reduced right hippocampal volumes, involving both gray and white matter. Amygdala and hippocampal volumes appear to be impacted by X-monosomy. Aberrant morphology in these regions may be related to the social cognition and memory deficits often experienced by individuals with TS. Further investigations of changes in medial temporal morphology associated with TS are warranted.

Original languageEnglish (US)
Pages (from-to)1971-1978
Number of pages8
Issue number14
StatePublished - 2004
Externally publishedYes


  • Amygdala
  • Hippocampus
  • MRI
  • Turner syndrome
  • X-monosomy

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience


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