The study objective was to obtain preliminary information regarding the safety and efficacy of amphotericin B (AraB) lipid complex (ABLC) in the treatment of AIDS-associated cryptococcal meningitis. Of 55 patients randomly assigned to 6 weeks of therapy with ABLC (1.2-5.0 mg/[kg-d], with ascending doses for three sequential cohorts) or Amb (0.7-1.2 mg/[kg-d]), 46 received ≥ 12 doses. Transfusion requirements, mean decreases in hemoglobin level, and mean increases in creatinine level were significantly greater with Arab than with ABLC. The total number of adverse events, infusion-related events, and occurrences of hypomagnesemia and hypokalemia associated with each form of therapy were similar. Among 21 recipients of ABLC at a dosage of 5 mg/kg (daily for 2 weeks and then thrice weekly for 4 weeks), symptoms and signs resolved for 18 (86%). Of those receiving ≥ 12 doses of ABLC, cultures converted to negative for 8 (42%), were undeterminable for 3 (16%), and remained positive for 8 (42%) despite resolution of symptoms. Although preliminary, these data suggest ABLC has significant activity in patients with AIDS-associated cryptococcal meningitis. Because this formulation has less hematologic and renal toxicity than does AraB, further evaluation of ABLC is warranted.
|Original language||English (US)|
|Number of pages||7|
|Journal||Clinical Infectious Diseases|
|Publication status||Published - Feb 1 1996|
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases