Amphotericin B-impregnated bone cement to treat refractory coccidioidal osteomyelitis

Elizabeth S. Zhu; George R. Thompson; Christopher Kreulen; Eric Giza

doi:10.1128/AAC.00963-13

Amphotericin B-impregnated bone cement to treat refractory coccidioidal osteomyelitis

Elizabeth S. Zhu, George R. Thompson, Christopher Kreulen, Eric Giza

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Use of amphotericin B-impregnated bone cement in combination with systemic antifungals for the treatment of coccidioidal osteomyelitis offers the potential for sustained local concentrations of drug at the site of the infection. Amphotericin B levels in bone of up to 5.1 μg/g have been demonstrated 4 months after placement of bone cement.

Original language	English (US)
Pages (from-to)	6341-6343
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	57
Issue number	12
DOIs	https://doi.org/10.1128/AAC.00963-13
State	Published - Dec 2013
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.00963-13

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title = "Amphotericin B-impregnated bone cement to treat refractory coccidioidal osteomyelitis",

abstract = "Use of amphotericin B-impregnated bone cement in combination with systemic antifungals for the treatment of coccidioidal osteomyelitis offers the potential for sustained local concentrations of drug at the site of the infection. Amphotericin B levels in bone of up to 5.1 μg/g have been demonstrated 4 months after placement of bone cement.",

author = "Zhu, {Elizabeth S.} and Thompson, {George R.} and Christopher Kreulen and Eric Giza",

year = "2013",

month = dec,

doi = "10.1128/AAC.00963-13",

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publisher = "American Society for Microbiology",

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AU - Zhu, Elizabeth S.

AU - Thompson, George R.

AU - Kreulen, Christopher

AU - Giza, Eric

PY - 2013/12

Y1 - 2013/12

N2 - Use of amphotericin B-impregnated bone cement in combination with systemic antifungals for the treatment of coccidioidal osteomyelitis offers the potential for sustained local concentrations of drug at the site of the infection. Amphotericin B levels in bone of up to 5.1 μg/g have been demonstrated 4 months after placement of bone cement.

AB - Use of amphotericin B-impregnated bone cement in combination with systemic antifungals for the treatment of coccidioidal osteomyelitis offers the potential for sustained local concentrations of drug at the site of the infection. Amphotericin B levels in bone of up to 5.1 μg/g have been demonstrated 4 months after placement of bone cement.

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ER -

Amphotericin B-impregnated bone cement to treat refractory coccidioidal osteomyelitis

Abstract

ASJC Scopus subject areas

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