TY - JOUR
T1 - Amphetamine use in the elderly
T2 - A systematic review of the literature
AU - Sassi, Karina Lúcia Moreira
AU - Rocha, Natalia Pessoa
AU - Colpo, Gabriela Delevati
AU - John, Vineeth
AU - Teixeira, Antonio Lucio
N1 - Publisher Copyright:
© 2020 Bentham Science Publishers.
PY - 2020
Y1 - 2020
N2 - Objective: To systematically review the literature on the therapeutic use of amphetamine, lisdexamfetamine and methylphenidate in elderly population with and without dementia. Methods: We conducted two researches on the PubMed, Scopus and Embase using the keywords (“elderly”) AND (“amphetamine” OR “methylphenidate” OR “lisdexamfetamine”) and then (“Alz-heimer” OR “dementia”) AND (“amphetamine” OR “methylphenidate” OR “lisdexamfetamine”). Results: Twenty-nine papers met all the eligibility criteria. The results are encouraging as 81.5% of the studies showed clinical improvement of the investigated condition. Conclusion: Amphetamines and methylphenidate are probably effective strategies for different conditions in the elderly population. However, further studies are needed to provide more robust evidence on efficacy, dosage and safety for this population.
AB - Objective: To systematically review the literature on the therapeutic use of amphetamine, lisdexamfetamine and methylphenidate in elderly population with and without dementia. Methods: We conducted two researches on the PubMed, Scopus and Embase using the keywords (“elderly”) AND (“amphetamine” OR “methylphenidate” OR “lisdexamfetamine”) and then (“Alz-heimer” OR “dementia”) AND (“amphetamine” OR “methylphenidate” OR “lisdexamfetamine”). Results: Twenty-nine papers met all the eligibility criteria. The results are encouraging as 81.5% of the studies showed clinical improvement of the investigated condition. Conclusion: Amphetamines and methylphenidate are probably effective strategies for different conditions in the elderly population. However, further studies are needed to provide more robust evidence on efficacy, dosage and safety for this population.
KW - Amphetamine
KW - Dementia
KW - Elderly
KW - Lisdexamfetamine
KW - Methylphenidate
KW - Stimulant
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U2 - 10.2174/1570159X17666191010093021
DO - 10.2174/1570159X17666191010093021
M3 - Review article
C2 - 31660835
AN - SCOPUS:85079019005
SN - 1570-159X
VL - 18
SP - 126
EP - 135
JO - Current Neuropharmacology
JF - Current Neuropharmacology
IS - 2
ER -