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AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells
Mengwei Zang
, Adriana Zuccollo
, Xiuyun Hou
, Daisuke Nagata
, Kenneth Walsh
, Haya Herscovitz
, Peter Brecher
, Neil B. Ruderman
, Richard A. Cohen
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Article
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peer-review
415
Scopus citations
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Dive into the research topics of 'AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells'. Together they form a unique fingerprint.
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Medicine and Dentistry
Hydroxymethylglutaryl Coenzyme A Reductase Kinase
100%
Glycon
72%
Lipid
63%
Carboxylase
45%
Acetyl-CoA
45%
Phosphorylation
36%
Glucose
36%
Cells
27%
Insulin
18%
Insulin Resistance
18%
Triacylglycerol
18%
Lipid Storage
18%
Glycogen Synthase Kinase 3
18%
Cyclic AMP Dependent Protein Kinase
9%
Antidiabetic Agent
9%
Skeletal Muscle
9%
Hepatocellular Carcinoma
9%
Cholesterol
9%
Phosphotransferase
9%
Regulatory Mechanism
9%
Aptitude
9%
Liver
9%
Biochemistry, Genetics and Molecular Biology
AMP-activated Protein Kinase
100%
Acetyl-CoA Carboxylase
45%
Phosphorylation
36%
Glucose
36%
Lipid
36%
Lipid Liver Level
27%
Insulin
18%
Kinase
18%
Insulin Resistance
18%
Lipid Storage
18%
Skeletal Muscle
9%
Cholesterol
9%
Time
9%
Regulatory Mechanism
9%
Aptitude
9%
Dose
9%