Amine Precursors and Depression

Joe Mendels, James L. Stinnett, David Burns, Alan Frazer

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


The amino acid precursors, levodopa and L-tryptophan, were given to a group of hospitalized depressed patients in a double-blind placebo controlled study. Relatively large doses were not associated with sufficient clinical improvement to allow the patients to leave the hospital. Previous studies using the precursor-load strategy have produced conflicting findings on the use of these compounds for depressed patients.

Original languageEnglish (US)
Pages (from-to)22-30
Number of pages9
JournalArchives of General Psychiatry
Issue number1
StatePublished - Jan 1975
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health


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