Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics

Christina L. Burnett; Wilma F. Bergfeld; Donald V. Belsito; David Cohen; Curtis D. Klaassen; Daniel C. Liebler; James G. Marks; Lisa A. Peterson; Ronald C. Shank; Thomas J. Slaga; Paul W. Snyder; Bart Heldreth

doi:10.1177/10915818211015795

Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics

Christina L. Burnett, Wilma F. Bergfeld, Donald V. Belsito, David Cohen, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Lisa A. Peterson, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Bart Heldreth

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The Expert Panel for Cosmetic Ingredient Safety (Panel) reassessed the safety of Methylisothiazolinone, which functions as a preservative in cosmetics. The Panel reviewed relevant animal and human data provided in this safety assessment, and data from the previously published safety assessments of Methylisothiazolinone, and concluded that Methylisothiazolinone is safe for use in rinse-off cosmetic products at concentrations up to 100 ppm (ie, 0.01%) and safe in leave-on cosmetic products when they are formulated to be nonsensitizing, which may be determined based on a quantitative risk assessment or similar methodology.

Original language	English (US)
Pages (from-to)	5S-19S
Journal	International journal of toxicology
Volume	40
Issue number	1_suppl
DOIs	https://doi.org/10.1177/10915818211015795
State	Published - Aug 2021
Externally published	Yes

Keywords

Methylisothiazolinone
cosmetics
safety

ASJC Scopus subject areas

Toxicology

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10.1177/10915818211015795

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title = "Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics",

abstract = "The Expert Panel for Cosmetic Ingredient Safety (Panel) reassessed the safety of Methylisothiazolinone, which functions as a preservative in cosmetics. The Panel reviewed relevant animal and human data provided in this safety assessment, and data from the previously published safety assessments of Methylisothiazolinone, and concluded that Methylisothiazolinone is safe for use in rinse-off cosmetic products at concentrations up to 100 ppm (ie, 0.01%) and safe in leave-on cosmetic products when they are formulated to be nonsensitizing, which may be determined based on a quantitative risk assessment or similar methodology.",

keywords = "Methylisothiazolinone, cosmetics, safety",

author = "Burnett, {Christina L.} and Bergfeld, {Wilma F.} and Belsito, {Donald V.} and David Cohen and Klaassen, {Curtis D.} and Liebler, {Daniel C.} and Marks, {James G.} and Peterson, {Lisa A.} and Shank, {Ronald C.} and Slaga, {Thomas J.} and Snyder, {Paul W.} and Bart Heldreth",

note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The articles in this supplement were sponsored by the Cosmetic Ingredient Review. The Cosmetic Ingredient Review is financially supported by the Personal Care Products Council. Publisher Copyright: {\textcopyright} The Author(s) 2021.",

year = "2021",

month = aug,

doi = "10.1177/10915818211015795",

language = "English (US)",

volume = "40",

pages = "5S--19S",

journal = "International Journal of Toxicology",

issn = "1091-5818",

publisher = "SAGE Publications Inc.",

number = "1_suppl",

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AU - Burnett, Christina L.

AU - Bergfeld, Wilma F.

AU - Belsito, Donald V.

AU - Cohen, David

AU - Klaassen, Curtis D.

AU - Liebler, Daniel C.

AU - Marks, James G.

AU - Peterson, Lisa A.

AU - Shank, Ronald C.

AU - Slaga, Thomas J.

AU - Snyder, Paul W.

AU - Heldreth, Bart

N1 - Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The articles in this supplement were sponsored by the Cosmetic Ingredient Review. The Cosmetic Ingredient Review is financially supported by the Personal Care Products Council. Publisher Copyright: © The Author(s) 2021.

PY - 2021/8

Y1 - 2021/8

N2 - The Expert Panel for Cosmetic Ingredient Safety (Panel) reassessed the safety of Methylisothiazolinone, which functions as a preservative in cosmetics. The Panel reviewed relevant animal and human data provided in this safety assessment, and data from the previously published safety assessments of Methylisothiazolinone, and concluded that Methylisothiazolinone is safe for use in rinse-off cosmetic products at concentrations up to 100 ppm (ie, 0.01%) and safe in leave-on cosmetic products when they are formulated to be nonsensitizing, which may be determined based on a quantitative risk assessment or similar methodology.

AB - The Expert Panel for Cosmetic Ingredient Safety (Panel) reassessed the safety of Methylisothiazolinone, which functions as a preservative in cosmetics. The Panel reviewed relevant animal and human data provided in this safety assessment, and data from the previously published safety assessments of Methylisothiazolinone, and concluded that Methylisothiazolinone is safe for use in rinse-off cosmetic products at concentrations up to 100 ppm (ie, 0.01%) and safe in leave-on cosmetic products when they are formulated to be nonsensitizing, which may be determined based on a quantitative risk assessment or similar methodology.

KW - Methylisothiazolinone

KW - cosmetics

KW - safety

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JO - International Journal of Toxicology

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IS - 1_suppl

ER -

Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics

Abstract

Keywords

ASJC Scopus subject areas

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