Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics

Christina L. Burnett, Ivan Boyer, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Lillian J. Gill, Bart Heldreth

Research output: Contribution to journalArticle

2 Scopus citations


The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of methylisothiazolinone (MI), which functions as a preservative. The Panel reviewed relevant animal and human data provided in this safety assessment and in a previously published safety assessment of MI and concluded that MI is safe for use in rinse-off cosmetic products at concentrations up to 100 ppm and safe in leave-on cosmetic products when they are formulated to be nonsensitizing, which may be determined based on a quantitative risk assessment.

Original languageEnglish (US)
Pages (from-to)70S-84S
JournalInternational Journal of Toxicology
Issue number1_suppl
StatePublished - May 1 2019
Externally publishedYes



  • cosmetics
  • methylisothiazolinone
  • safety

ASJC Scopus subject areas

  • Toxicology

Cite this

Burnett, C. L., Boyer, I., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., Marks, J. G., Shank, R. C., Slaga, T. J., Snyder, P. W., Gill, L. J., & Heldreth, B. (2019). Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics. International Journal of Toxicology, 38(1_suppl), 70S-84S.