Amended Safety Assessment of Isethionate Salts as Used in Cosmetics

Christina L. Burnett, Bart Heldreth, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen, Lillian J. Gill

Research output: Contribution to journalReview article

Abstract

The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) rereviewed the safety of 12 isethionate salts as used in cosmetics and concluded that these ingredients are safe in the present practices of use and concentration, when formulated to be nonirritating. These isethionate salts are reported to function mostly as surfactants and cleansing agents in cosmetic products. The Panel reviewed the available animal and clinical data as well as information from previous CIR reports. Although there are data gaps, the shared chemical core structure, expected similarities in physicochemical properties, and similar functions and concentrations in cosmetics enabled grouping these ingredients and reading across the available toxicological data to support the safety assessment of each ingredient.

Original languageEnglish (US)
Pages (from-to)5S-16S
JournalInternational journal of toxicology
Volume36
Issue number1_suppl
DOIs
StatePublished - May 1 2017
Externally publishedYes

Keywords

  • cosmetics
  • isethionate salts
  • safety

ASJC Scopus subject areas

  • Toxicology

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  • Cite this

    Burnett, C. L., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., Marks, J. G., Shank, R. C., Slaga, T. J., Snyder, P. W., Andersen, F. A., & Gill, L. J. (2017). Amended Safety Assessment of Isethionate Salts as Used in Cosmetics. International journal of toxicology, 36(1_suppl), 5S-16S. https://doi.org/10.1177/1091581816685552