@article{e2a11d16597b493d98cfa0d93234d369,
title = "Alzheimer's Disease Genetic Risk, Cognition, and Brain Aging in Midlife",
abstract = "We examined associations of an Alzheimer's disease (AD) Genetic Risk Score (AD-GRS) and midlife cognitive and neuroimaging outcomes in 1,252 middle-aged participants (311 with brain MRI). A higher AD-GRS based on 25 previously identified loci (excluding apolipoprotein E [APOE]) was associated with worse Montreal Cognitive Assessment (−0.14 standard deviation [SD] [95% confidence interval {CI}: -0.26, −0.02]), older machine learning predicted brain age (2.35 years[95%CI: 0.01, 4.69]), and white matter hyperintensity volume (0.35 SD [95% CI: 0.00, 0.71]), but not with a composite cognitive outcome, total brain, or hippocampal volume. APOE ε4 allele was not associated with any outcomes. AD risk genes beyond APOE may contribute to subclinical differences in cognition and brain health in midlife. ANN NEUROL 2023;93:629–634.",
author = "Brenowitz, {Willa D.} and Myriam Fornage and Launer, {Lenore J.} and Mohamad Habes and Christos Davatzikos and Kristine Yaffe",
note = "Funding Information: We are deeply grateful to all of the CARDIA study participants, clinicians, and staff that made this research possible. CARDIA is supported by contracts HHSN268201800003I, HHSN268201800004I, HHSN268201800005I, HHSN268201800006I, and HHSN268201800007I from the National Heart, Lung, and Blood Institute (NHLBI). CARDIA was also partially supported by the Intramural Research Program of the National Institute on Aging (NIA) and an intra‐agency agreement between NIA and NHLBI (AG0005). This work was also supported in part by NIH grants K01AG062722, U01AG052409, R35AG071916, 1R01AG080821, P30AG066546, 1U24AG074855, and the San Antonio Medical Foundation grant SAMF – 1000003860. Funding Information: WDB, MF, MH, and KY report grant funding from NIH. None of the funding sources had involvement in the conduct of this research or preparation of the manuscript. Unrelated to this current study, KY is a Board Member of Alector. Publisher Copyright: {\textcopyright} 2022 American Neurological Association.",
year = "2023",
month = mar,
doi = "10.1002/ana.26569",
language = "English (US)",
volume = "93",
pages = "629--634",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "3",
}