Abstract
Persons who suffer traumatic injury are likely to be transfused with considerable amounts of blood during initial resuscitation efforts. Oxygen-carrying solutions are currently in clinical testing as substitutes for red blood cells. Although these agents may eliminate many concerns associated with blood administration (short shelf life, infectious and immunologic risks, the need to type and cross-match), early cell-free hemoglobin solutions demonstrated nephrotoxicity and were associated with pulmonary and systemic hypertension, among other adverse events. Newer polymerized hemoglobin solutions show acceptable safety profiles in the surgical setting and studies are being designed, some with funding from the US Department of Defense, to evaluate their efficacy in hemorrhaging trauma victims.
| Original language | English (US) |
|---|---|
| Journal | Critical Care |
| Volume | 8 |
| Issue number | SUPPL. 2 |
| DOIs | |
| State | Published - Jun 2004 |
| Externally published | Yes |
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Keywords
- Blood substitutes
- Hemorrhage
- Injury
- Trauma
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
Cite this
Alternatives to blood in the 21st century. / Cohn, Stephen M.
In: Critical Care, Vol. 8, No. SUPPL. 2, 06.2004.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alternatives to blood in the 21st century
AU - Cohn, Stephen M.
PY - 2004/6
Y1 - 2004/6
N2 - Persons who suffer traumatic injury are likely to be transfused with considerable amounts of blood during initial resuscitation efforts. Oxygen-carrying solutions are currently in clinical testing as substitutes for red blood cells. Although these agents may eliminate many concerns associated with blood administration (short shelf life, infectious and immunologic risks, the need to type and cross-match), early cell-free hemoglobin solutions demonstrated nephrotoxicity and were associated with pulmonary and systemic hypertension, among other adverse events. Newer polymerized hemoglobin solutions show acceptable safety profiles in the surgical setting and studies are being designed, some with funding from the US Department of Defense, to evaluate their efficacy in hemorrhaging trauma victims.
AB - Persons who suffer traumatic injury are likely to be transfused with considerable amounts of blood during initial resuscitation efforts. Oxygen-carrying solutions are currently in clinical testing as substitutes for red blood cells. Although these agents may eliminate many concerns associated with blood administration (short shelf life, infectious and immunologic risks, the need to type and cross-match), early cell-free hemoglobin solutions demonstrated nephrotoxicity and were associated with pulmonary and systemic hypertension, among other adverse events. Newer polymerized hemoglobin solutions show acceptable safety profiles in the surgical setting and studies are being designed, some with funding from the US Department of Defense, to evaluate their efficacy in hemorrhaging trauma victims.
KW - Blood substitutes
KW - Hemorrhage
KW - Injury
KW - Trauma
UR - http://www.scopus.com/inward/record.url?scp=4344711659&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4344711659&partnerID=8YFLogxK
U2 - 10.1186/cc2412
DO - 10.1186/cc2412
M3 - Article
C2 - 15196316
AN - SCOPUS:4344711659
VL - 8
JO - Critical Care
JF - Critical Care
SN - 1466-609X
IS - SUPPL. 2
ER -