Alternatives to blood in the 21st century

Stephen M. Cohn

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Persons who suffer traumatic injury are likely to be transfused with considerable amounts of blood during initial resuscitation efforts. Oxygen-carrying solutions are currently in clinical testing as substitutes for red blood cells. Although these agents may eliminate many concerns associated with blood administration (short shelf life, infectious and immunologic risks, the need to type and cross-match), early cell-free hemoglobin solutions demonstrated nephrotoxicity and were associated with pulmonary and systemic hypertension, among other adverse events. Newer polymerized hemoglobin solutions show acceptable safety profiles in the surgical setting and studies are being designed, some with funding from the US Department of Defense, to evaluate their efficacy in hemorrhaging trauma victims.

Original languageEnglish (US)
JournalCritical Care
Volume8
Issue numberSUPPL. 2
DOIs
StatePublished - Jun 2004
Externally publishedYes

Fingerprint

United States Department of Defense
Hemoglobins
Wounds and Injuries
Pulmonary Hypertension
Resuscitation
Erythrocytes
Oxygen
Safety

Keywords

  • Blood substitutes
  • Hemorrhage
  • Injury
  • Trauma

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Alternatives to blood in the 21st century. / Cohn, Stephen M.

In: Critical Care, Vol. 8, No. SUPPL. 2, 06.2004.

Research output: Contribution to journalArticle

Cohn, Stephen M. / Alternatives to blood in the 21st century. In: Critical Care. 2004 ; Vol. 8, No. SUPPL. 2.
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