Alternative variants of human HYDIN are novel cancer-associated antigens recognized by adaptive immunity

Karoline Laske, Yuriy V. Shebzukhov, Ludger Grosse-Hovest, Dmitry V. Kuprash, Svetlana V. Khlgatian, Ekaterina P. Koroleva, Alexey Y. Sazykin, Dmitry N. Penkov, Pavel V. Belousov, Stefan Stevanovic, Verona Vass, Steffen Walter, David Eisel, Barbara D. Schmid-Horch, Sergei A. Nedospasov, Hans Georg Rammensee, Cécile Gouttefangeas

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

A mutation in the hydin gene has been recently described as one possible mechanism leading to lethal congenital hydrocephalus in mice, and a similar defect is proposed to be involved in an autosomal recessive form of hydrocephalus in human. Here, we report for the first time on the cancer association and immunogenicity of two HYDIN variants in humans. One is a previously described sequence derived from the chromosome 1 gene copy, that is, KIAA1864. The second is encoded by a novel alternative transcript originating from the chromosome 16, which we identified by immunoscreening of a testis-derived cDNA expression library with sera of patients with colorectal cancer, and called MO-TES391. Both variants are targeted by immunoglobulin G antibodies in a significant subset of cancer patients but only rarely in healthy donors. Moreover, we identify HLA-A*0201-restricted sequences derived from MO-TES391 and KIAA1864, which are specifically recognized by human cytotoxic CD8(+) T cells. Taken together, these results suggest frequent and coordinated adaptive immune responses against HYDIN variants in patients with cancer and propose HYDIN as a novel cancer-associated antigen.

Original languageEnglish (US)
Pages (from-to)190-200
Number of pages11
JournalCancer Immunology Research
Volume1
Issue number3
DOIs
StatePublished - Sep 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Cancer Research

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