Altered resting-state network connectivity in stroke patients with and without apraxia of speech

Anneliese B. New, Donald A. Robin, Amy L. Parkinson, Joseph R. Duffy, Malcom R. McNeil, Olivier Piguet, Michael Hornberger, Cathy J. Price, Simon B. Eickhoff, Kirrie J. Ballard

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Motor speech disorders, including apraxia of speech (AOS), account for over 50% of the communication disorders following stroke. Given its prevalence and impact, and the need to understand its neural mechanisms, we used resting state functional MRI to examine functional connectivity within a network of regions previously hypothesized as being associated with AOS (bilateral anterior insula (aINS), inferior frontal gyrus (IFG), and ventral premotor cortex (PM)) in a group of 32 left hemisphere stroke patients and 18 healthy, age-matched controls. Two expert clinicians rated severity of AOS, dysarthria and nonverbal oral apraxia of the patients. Fifteen individuals were categorized as AOS and 17 were AOS-absent. Comparison of connectivity in patients with and without AOS demonstrated that AOS patients had reduced connectivity between bilateral PM, and this reduction correlated with the severity of AOS impairment. In addition, AOS patients had negative connectivity between the left PM and right aINS and this effect decreased with increasing severity of non-verbal oral apraxia. These results highlight left PM involvement in AOS, begin to differentiate its neural mechanisms from those of other motor impairments following stroke, and help inform us of the neural mechanisms driving differences in speech motor planning and programming impairment following stroke.

Original languageEnglish (US)
Pages (from-to)429-439
Number of pages11
JournalNeuroImage: Clinical
Volume8
DOIs
StatePublished - Jun 8 2015

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Apraxias
Stroke
Motor Cortex
Communication Disorders
Speech Disorders
Dysarthria
Prefrontal Cortex

Keywords

  • Apraxia of speech
  • Network connectivity
  • Resting-state fMRI
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Cognitive Neuroscience
  • Neurology

Cite this

New, A. B., Robin, D. A., Parkinson, A. L., Duffy, J. R., McNeil, M. R., Piguet, O., ... Ballard, K. J. (2015). Altered resting-state network connectivity in stroke patients with and without apraxia of speech. NeuroImage: Clinical, 8, 429-439. https://doi.org/10.1016/j.nicl.2015.03.013

Altered resting-state network connectivity in stroke patients with and without apraxia of speech. / New, Anneliese B.; Robin, Donald A.; Parkinson, Amy L.; Duffy, Joseph R.; McNeil, Malcom R.; Piguet, Olivier; Hornberger, Michael; Price, Cathy J.; Eickhoff, Simon B.; Ballard, Kirrie J.

In: NeuroImage: Clinical, Vol. 8, 08.06.2015, p. 429-439.

Research output: Contribution to journalArticle

New, AB, Robin, DA, Parkinson, AL, Duffy, JR, McNeil, MR, Piguet, O, Hornberger, M, Price, CJ, Eickhoff, SB & Ballard, KJ 2015, 'Altered resting-state network connectivity in stroke patients with and without apraxia of speech', NeuroImage: Clinical, vol. 8, pp. 429-439. https://doi.org/10.1016/j.nicl.2015.03.013
New, Anneliese B. ; Robin, Donald A. ; Parkinson, Amy L. ; Duffy, Joseph R. ; McNeil, Malcom R. ; Piguet, Olivier ; Hornberger, Michael ; Price, Cathy J. ; Eickhoff, Simon B. ; Ballard, Kirrie J. / Altered resting-state network connectivity in stroke patients with and without apraxia of speech. In: NeuroImage: Clinical. 2015 ; Vol. 8. pp. 429-439.
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