Altered NMDA receptor trafficking contributes to sleep deprivation-induced hippocampal synaptic and cognitive impairments

Chu Chen; Mattie Hardy; Jian Zhang; Gerald J. LaHoste; Nicolas G. Bazan

doi:10.1016/j.bbrc.2005.12.021

Altered NMDA receptor trafficking contributes to sleep deprivation-induced hippocampal synaptic and cognitive impairments

Chu Chen, Mattie Hardy, Jian Zhang, Gerald J. LaHoste, Nicolas G. Bazan

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

Abstract

Recent evidence indicates that continuous wakefulness (sleep deprivation, SD) causes impairments in behavioral performance and hippocampal long-term potentiation (LTP) in animals. However, the mechanisms by which SD impairs long-term synaptic plasticity and cognitive function are not clear. Here, we report that 24-h SD in mice results in impaired hippocampus-dependent contextual memory and LTP and, unexpectedly, in reductions of the surface expression of NMDA receptor (NMDAR) subunit NR1 and NMDAR-mediated excitatory post-synaptic currents at hippocampal perforant path-dentate granule cell synapses. The results suggest that the reduction of functional NMDAR in hippocampal neurons may underlie the SD-induced deficits in hippocampus-dependent contextual memory and long-term synaptic plasticity.

Original language	English (US)
Pages (from-to)	435-440
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	340
Issue number	2
DOIs	https://doi.org/10.1016/j.bbrc.2005.12.021
State	Published - Feb 10 2006
Externally published	Yes

Keywords

Hippocampus-dependent contextual memory
Long-term potentiation
Rapid eye movement sleep

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2005.12.021

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@article{a648318210fe4f7e96e262f0f6325296,

title = "Altered NMDA receptor trafficking contributes to sleep deprivation-induced hippocampal synaptic and cognitive impairments",

abstract = "Recent evidence indicates that continuous wakefulness (sleep deprivation, SD) causes impairments in behavioral performance and hippocampal long-term potentiation (LTP) in animals. However, the mechanisms by which SD impairs long-term synaptic plasticity and cognitive function are not clear. Here, we report that 24-h SD in mice results in impaired hippocampus-dependent contextual memory and LTP and, unexpectedly, in reductions of the surface expression of NMDA receptor (NMDAR) subunit NR1 and NMDAR-mediated excitatory post-synaptic currents at hippocampal perforant path-dentate granule cell synapses. The results suggest that the reduction of functional NMDAR in hippocampal neurons may underlie the SD-induced deficits in hippocampus-dependent contextual memory and long-term synaptic plasticity.",

keywords = "Hippocampus-dependent contextual memory, Long-term potentiation, Rapid eye movement sleep",

author = "Chu Chen and Mattie Hardy and Jian Zhang and LaHoste, \{Gerald J.\} and Bazan, \{Nicolas G.\}",

note = "Funding Information: We thank Ms. B. Chiappinelli, C. Liu and K.E. Dunn for technical help. This work was supported by United States Public Health Service Grants P20RR16816 from the COBRE Program, National Center for Research Resources, National Institutes of Health.",

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doi = "10.1016/j.bbrc.2005.12.021",

language = "English (US)",

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journal = "Biochemical and Biophysical Research Communications",

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T1 - Altered NMDA receptor trafficking contributes to sleep deprivation-induced hippocampal synaptic and cognitive impairments

AU - Chen, Chu

AU - Hardy, Mattie

AU - Zhang, Jian

AU - LaHoste, Gerald J.

AU - Bazan, Nicolas G.

N1 - Funding Information: We thank Ms. B. Chiappinelli, C. Liu and K.E. Dunn for technical help. This work was supported by United States Public Health Service Grants P20RR16816 from the COBRE Program, National Center for Research Resources, National Institutes of Health.

PY - 2006/2/10

Y1 - 2006/2/10

N2 - Recent evidence indicates that continuous wakefulness (sleep deprivation, SD) causes impairments in behavioral performance and hippocampal long-term potentiation (LTP) in animals. However, the mechanisms by which SD impairs long-term synaptic plasticity and cognitive function are not clear. Here, we report that 24-h SD in mice results in impaired hippocampus-dependent contextual memory and LTP and, unexpectedly, in reductions of the surface expression of NMDA receptor (NMDAR) subunit NR1 and NMDAR-mediated excitatory post-synaptic currents at hippocampal perforant path-dentate granule cell synapses. The results suggest that the reduction of functional NMDAR in hippocampal neurons may underlie the SD-induced deficits in hippocampus-dependent contextual memory and long-term synaptic plasticity.

AB - Recent evidence indicates that continuous wakefulness (sleep deprivation, SD) causes impairments in behavioral performance and hippocampal long-term potentiation (LTP) in animals. However, the mechanisms by which SD impairs long-term synaptic plasticity and cognitive function are not clear. Here, we report that 24-h SD in mice results in impaired hippocampus-dependent contextual memory and LTP and, unexpectedly, in reductions of the surface expression of NMDA receptor (NMDAR) subunit NR1 and NMDAR-mediated excitatory post-synaptic currents at hippocampal perforant path-dentate granule cell synapses. The results suggest that the reduction of functional NMDAR in hippocampal neurons may underlie the SD-induced deficits in hippocampus-dependent contextual memory and long-term synaptic plasticity.

KW - Hippocampus-dependent contextual memory

KW - Long-term potentiation

KW - Rapid eye movement sleep

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SN - 0006-291X

VL - 340

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EP - 440

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

Altered NMDA receptor trafficking contributes to sleep deprivation-induced hippocampal synaptic and cognitive impairments

Abstract

Keywords

ASJC Scopus subject areas

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