Altered NMDA receptor trafficking contributes to sleep deprivation-induced hippocampal synaptic and cognitive impairments

Chu Chen, Mattie Hardy, Jian Zhang, Gerald J. LaHoste, Nicolas G. Bazan

Research output: Contribution to journalArticlepeer-review

87 Scopus citations

Abstract

Recent evidence indicates that continuous wakefulness (sleep deprivation, SD) causes impairments in behavioral performance and hippocampal long-term potentiation (LTP) in animals. However, the mechanisms by which SD impairs long-term synaptic plasticity and cognitive function are not clear. Here, we report that 24-h SD in mice results in impaired hippocampus-dependent contextual memory and LTP and, unexpectedly, in reductions of the surface expression of NMDA receptor (NMDAR) subunit NR1 and NMDAR-mediated excitatory post-synaptic currents at hippocampal perforant path-dentate granule cell synapses. The results suggest that the reduction of functional NMDAR in hippocampal neurons may underlie the SD-induced deficits in hippocampus-dependent contextual memory and long-term synaptic plasticity.

Original languageEnglish (US)
Pages (from-to)435-440
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume340
Issue number2
DOIs
StatePublished - Feb 10 2006
Externally publishedYes

Keywords

  • Hippocampus-dependent contextual memory
  • Long-term potentiation
  • Rapid eye movement sleep

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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