TY - JOUR
T1 - Altered NMDA receptor trafficking contributes to sleep deprivation-induced hippocampal synaptic and cognitive impairments
AU - Chen, Chu
AU - Hardy, Mattie
AU - Zhang, Jian
AU - LaHoste, Gerald J.
AU - Bazan, Nicolas G.
N1 - Funding Information:
We thank Ms. B. Chiappinelli, C. Liu and K.E. Dunn for technical help. This work was supported by United States Public Health Service Grants P20RR16816 from the COBRE Program, National Center for Research Resources, National Institutes of Health.
PY - 2006/2/10
Y1 - 2006/2/10
N2 - Recent evidence indicates that continuous wakefulness (sleep deprivation, SD) causes impairments in behavioral performance and hippocampal long-term potentiation (LTP) in animals. However, the mechanisms by which SD impairs long-term synaptic plasticity and cognitive function are not clear. Here, we report that 24-h SD in mice results in impaired hippocampus-dependent contextual memory and LTP and, unexpectedly, in reductions of the surface expression of NMDA receptor (NMDAR) subunit NR1 and NMDAR-mediated excitatory post-synaptic currents at hippocampal perforant path-dentate granule cell synapses. The results suggest that the reduction of functional NMDAR in hippocampal neurons may underlie the SD-induced deficits in hippocampus-dependent contextual memory and long-term synaptic plasticity.
AB - Recent evidence indicates that continuous wakefulness (sleep deprivation, SD) causes impairments in behavioral performance and hippocampal long-term potentiation (LTP) in animals. However, the mechanisms by which SD impairs long-term synaptic plasticity and cognitive function are not clear. Here, we report that 24-h SD in mice results in impaired hippocampus-dependent contextual memory and LTP and, unexpectedly, in reductions of the surface expression of NMDA receptor (NMDAR) subunit NR1 and NMDAR-mediated excitatory post-synaptic currents at hippocampal perforant path-dentate granule cell synapses. The results suggest that the reduction of functional NMDAR in hippocampal neurons may underlie the SD-induced deficits in hippocampus-dependent contextual memory and long-term synaptic plasticity.
KW - Hippocampus-dependent contextual memory
KW - Long-term potentiation
KW - Rapid eye movement sleep
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U2 - 10.1016/j.bbrc.2005.12.021
DO - 10.1016/j.bbrc.2005.12.021
M3 - Article
C2 - 16376302
AN - SCOPUS:29644438259
SN - 0006-291X
VL - 340
SP - 435
EP - 440
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -