Altered K+ channel expression in abnormal T lymphocytes from mice with the lpr gene mutation

K. George Chandy, Thomas E. Decoursey, Michael Fischbach, Norman Talal, Michael D. Cahalan, Sudhir Gupta

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

The observation that voltage-dependent K+ channels are required for activation of human T lymphocytes suggests that pathological conditions involving abnormal mitogen responses might be reflected in ion channel abnormalities. Gigaohm seal techniques were used to study T cells from MRL/MpJ-lpr/lpr mice; these mice develop generalized lymphoproliferation of functionally and phenotypically abnormal T cells and a disease resembling human systemic lupus erythematosus. The number and predominant type of K+ channels in T cells from these mice differ dramatically from those in T cells from control strains and a congenic strain lacking the lpr gene locus. Thus an abnormal pattern of ion channel expression has now been associated with a genetic defect in cells of the immune system.

Original languageEnglish (US)
Pages (from-to)1197-1200
Number of pages4
JournalScience
Volume233
Issue number4769
DOIs
StatePublished - 1986

ASJC Scopus subject areas

  • General

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