Altered immune response in adult women exposed to diethylstilbestrol in utero

Louis Burke, Margot Segall-Blank, Carlos Lorenzo, Roselynn Dynesius-Trentham, David Trentham, Joseph F. Mortola

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

OBJECTIVE: Between 1940 and 1970, 1.5 million female fetuses were exposed to diethylstilbestrol in utero. Numerous deleterious effects on reproductive anatomic and physiologic characteristics have been documented in these women. However, the effects of this exposure on nonreproductive systems, which may have lifelong consequences as this cohort of women progresses beyond the childbearing years, have received little attention. On the basis of an earlier preliminary observation of altered immune reponse, we hypothesized that diethylstilbestrol-exposed women may show abnormalities in T-cell-mediated immune response. STUDY DESIGN: Thirteen women exposed to diethylstilbestrol in utero were compared with 13 age- and menstrual cycle phase-matched control subjects with respect to the in vitro T-cell response to the mitogens phytohemagglutinin, concanavalin A, and interleukin 2. RESULTS: As compared with controls, tritiated thymidine incorporation by T cells harvested from diethylstilbestrol-exposed women was increased 3-fold over a range of concentrations in response to concanavalin A (P <. 001), increased by 50% over a range of concentrations in response to phytohemagglutinin (P <. 001), and increased 2-fold in response to the endogenous mitogen interleukin 2 (P <. 05). CONCLUSIONS: In vitro evidence suggests that women exposed to diethylstilbestrol have alterations in T-cell-mediated immunity. These changes require further attention with regard to their characterization, their role in the pathogenesis of cancer and autoimmunity, and their presence in normal women exposed to diethylstilbestrol in utero.

Original languageEnglish (US)
Pages (from-to)78-81
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Volume185
Issue number1
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Keywords

  • Autoimmune disease
  • DES
  • Diethylstilbestrol
  • Immunocompetence
  • T cells

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Altered immune response in adult women exposed to diethylstilbestrol in utero'. Together they form a unique fingerprint.

Cite this