Altered global brai

Genevieve J. Yang, John D. Murray, Grega Repovs, Michael W. Cole, Aleksandar Savic, Matthew F. Glasser, Christopher Pittenger, John H. Krystal, Xiao Jing Wang, Godfrey D. Pearlson, David C. Glahn, Alan Anticevic

Research output: Contribution to journalArticle

199 Scopus citations

Abstract

Neuropsychiatric conditions like schizophrenia display a complex neurobiology, which has long been associated with distributed brain dysfunction. However, no investigation has tested whether schizophrenia shows alterations in global brain signal (GS), a signal derived from functional MRI and often discarded as a meaningless baseline in many studies. To evaluate GS alterations associated with schizophrenia, we studied two large chronic patient samples (n = 90, n = 71), comparing them to healthy subjects (n = 220) and patients diagnosed with bipolar disorder (n = 73). We identified and replicated increased cortical power and variance in schizophrenia, an effect predictive of symptoms yet obscured by GS removal. Voxel-wise signal variance was also increased in schizophrenia, independent of GS effects. Both findings were absent in bipolar patients, confirming diagnostic specificity. Biologically informed computational modeling of shared and nonshared signal propagation through the brain suggests that these findings may be explained by altered net strength of overall brain connectivity in schizophrenia.

Original languageEnglish (US)
Pages (from-to)7438-7443
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume111
Issue number20
DOIs
StatePublished - May 20 2014
Externally publishedYes

ASJC Scopus subject areas

  • General

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