Alterations in the rate of hemoglobin synthesis during chick embryogenesis

Frederick Grinnell, John C. Lee

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The rate of synthesis of different hemoglobin (Hb) species — embryonic, primitive, definitive, and adult — in the circulating red cells of the chick embryo have been measured. On the fifth day of chick embryogenesis, there is a marked decrease in the capability of these red cells to synthesize Hb. The rates of synthesis of embryonic and primitive Hb decrease markedly compared to that of definitive and adult Hb. On the fourth day of embryogenesis nucleic acid synthesis drops sharply in these cells. These decreases in metabolic activity preceed the disappearance of the primitive erythrocyte from the chick embryo circulation. It appears that the primitive cell line is specifically shut off with respect to its metabolic activities and possibly destroyed at this time.

Original languageEnglish (US)
Pages (from-to)111-116
Number of pages6
JournalJournal of Cellular Physiology
Issue number1
StatePublished - Feb 1972

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology


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