Alterations in the rate of hemoglobin synthesis during chick embryogenesis

Frederick Grinnell, John C. Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The rate of synthesis of different hemoglobin (Hb) species — embryonic, primitive, definitive, and adult — in the circulating red cells of the chick embryo have been measured. On the fifth day of chick embryogenesis, there is a marked decrease in the capability of these red cells to synthesize Hb. The rates of synthesis of embryonic and primitive Hb decrease markedly compared to that of definitive and adult Hb. On the fourth day of embryogenesis nucleic acid synthesis drops sharply in these cells. These decreases in metabolic activity preceed the disappearance of the primitive erythrocyte from the chick embryo circulation. It appears that the primitive cell line is specifically shut off with respect to its metabolic activities and possibly destroyed at this time.

Original languageEnglish (US)
Pages (from-to)111-116
Number of pages6
JournalJournal of Cellular Physiology
Volume79
Issue number1
DOIs
StatePublished - 1972

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Embryonic Development
Hemoglobins
Cells
Chick Embryo
Nucleic Acids
Erythrocytes
Cell Line

ASJC Scopus subject areas

  • Physiology
  • Medicine(all)
  • Clinical Biochemistry
  • Cell Biology

Cite this

Alterations in the rate of hemoglobin synthesis during chick embryogenesis. / Grinnell, Frederick; Lee, John C.

In: Journal of Cellular Physiology, Vol. 79, No. 1, 1972, p. 111-116.

Research output: Contribution to journalArticle

Grinnell, Frederick ; Lee, John C. / Alterations in the rate of hemoglobin synthesis during chick embryogenesis. In: Journal of Cellular Physiology. 1972 ; Vol. 79, No. 1. pp. 111-116.
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