Alterations in the hepatic enzymes following experimental lead poisoning

B. Nehru; S. Kaushal

doi:10.1007/BF02783979

Alterations in the hepatic enzymes following experimental lead poisoning

B. Nehru, S. Kaushal

Molecular Medicine

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

An investigation on the influence of lead toxicity on some of the hepatic enzymes was studied in rats both after a shorter interval of 15 d and after longer intervals of 60 and 90 d. Three different doses of lead as 5, 10, and 50 mg/kg body wt were administered orally on every alternate day. Whereas significant inhibition of succinic dehydrogenase was seen following lead poisoning, the activity acid and alkaline phosphatase increased with lead intoxication. The histoarchitecture of the liver was grossly intact. Liver accumulated less lead compared to kidney at 60 and 90 d.

Original language	English (US)
Pages (from-to)	27-34
Number of pages	8
Journal	Biological Trace Element Research
Volume	38
Issue number	1
DOIs	https://doi.org/10.1007/BF02783979
State	Published - Jul 1 1993

Keywords

Lead
acetate
lead concentration
liver enzymes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Clinical Biochemistry
Biochemistry, medical
Inorganic Chemistry

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