Alterations in the hepatic enzymes following experimental lead poisoning

B. Nehru, S. Kaushal

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

An investigation on the influence of lead toxicity on some of the hepatic enzymes was studied in rats both after a shorter interval of 15 d and after longer intervals of 60 and 90 d. Three different doses of lead as 5, 10, and 50 mg/kg body wt were administered orally on every alternate day. Whereas significant inhibition of succinic dehydrogenase was seen following lead poisoning, the activity acid and alkaline phosphatase increased with lead intoxication. The histoarchitecture of the liver was grossly intact. Liver accumulated less lead compared to kidney at 60 and 90 d.

Original languageEnglish (US)
Pages (from-to)27-34
Number of pages8
JournalBiological Trace Element Research
Volume38
Issue number1
DOIs
StatePublished - Jul 1 1993

Keywords

  • Lead
  • acetate
  • lead concentration
  • liver enzymes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical
  • Inorganic Chemistry

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