Alterations in Skeletal Muscle Related to Short-Term Impaired Physical Mobility

Christine E. Kasper, Leo C. Maxwell, Timothy P. White

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The purpose of this investigation was to describe and compare two methods of recovery of atrophied skeletal muscle following short-term impaired physical mobility. An animal model was used to study morphologic adaptations of atrophied soleus and plantaris muscles to the effects of 7 days of hind-limb suspension (HS) followed by either sedentary recovery or run training during a 28-day recovery period. Significant atrophy, demonstrated by decreased mean fiber area (MFA, in square micrometers), occurred during the 7-day period of HS. During recovery, MFA returned to control values 14 days earlier in the sedentary compared with the trained groups. Run training following short-term atrophy induced by HS did not result in the high levels of frank muscle damage and type IIC fibers previously reported following long-term (28-day) atrophy.

Original languageEnglish (US)
Pages (from-to)133-142
Number of pages10
JournalResearch in Nursing and Health
Issue number2
StatePublished - Apr 1996

ASJC Scopus subject areas

  • Nursing(all)


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