TY - JOUR
T1 - Alterations in regional ventilation, perfusion, and shunt after smoke inhalation measured by PET
AU - Willey-Courand, Donna Beth
AU - Scott Harris, R.
AU - Galletti, Gaetano G.
AU - Hales, C. A.
AU - Fischman, Alan
AU - Venegas, Jose G.
PY - 2002/9
Y1 - 2002/9
N2 - Regional changes in ventilation and perfusion occurring in the early hours after smoke inhalation injury were evaluated through the use of positron emission tomography. Five lambs were imaged before and 1, 2, and 4 h after receiving 100 breaths of cotton smoke. Utilizing a recently developed model of 13N tracer kinetics (3), we evaluated changes in ventilation, perfusion, shunt, and regional gas content in nondependent, middle, and dependent lung zones. The data demonstrated a progressive development of regional shunt in dependent (dorsal) regions in which perfusion remained the highest throughout the study. These findings, together with decreasing regional ventilation and fractional gas content in the dependent regions, correlated with decreasing arterial PaO2 values over the course of the study. A negative correlation between regional shunt fraction and regional gas content in dependent and middle regions suggests that shunt was caused by progressive alveolar derecruitment or flooding.
AB - Regional changes in ventilation and perfusion occurring in the early hours after smoke inhalation injury were evaluated through the use of positron emission tomography. Five lambs were imaged before and 1, 2, and 4 h after receiving 100 breaths of cotton smoke. Utilizing a recently developed model of 13N tracer kinetics (3), we evaluated changes in ventilation, perfusion, shunt, and regional gas content in nondependent, middle, and dependent lung zones. The data demonstrated a progressive development of regional shunt in dependent (dorsal) regions in which perfusion remained the highest throughout the study. These findings, together with decreasing regional ventilation and fractional gas content in the dependent regions, correlated with decreasing arterial PaO2 values over the course of the study. A negative correlation between regional shunt fraction and regional gas content in dependent and middle regions suggests that shunt was caused by progressive alveolar derecruitment or flooding.
KW - Positron emission tomography
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U2 - 10.1152/japplphysiol.00911.2001
DO - 10.1152/japplphysiol.00911.2001
M3 - Article
C2 - 12183509
AN - SCOPUS:0036707849
SN - 8750-7587
VL - 93
SP - 1115
EP - 1122
JO - Journal of applied physiology
JF - Journal of applied physiology
IS - 3
ER -