Alterations in oxygen saturation and ventilation after intravenous sedation for peritoneoscopy

C. E. Brady, L. E. Harkleroad, W. P. Pierson

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


The effect of intravenous sedation on oxygen saturation and ventilation was studied in 11 patients undergoing peritoneoscopy. Oxygen saturation (mean ± SD) decreased from baseline (94.7% ± 1.7%) to nadir (78.6% ± 10.7%) after sedation. Respiratory depression was evident in these patients by concomitant decreases in minute ventilation and tidal volume. Baseline to nadir arterial blood gas changes in eight patients were consistent with hypoventilation and also suggested a superimposed ventilation perfusion mismatch. Mean respiratory rate did not significantly change during peritoneoscopy. Peritoneal gas insufflation stimulated increased ventilation and oxygen saturation, but no further changes in PCO2 or pH. We conclude that serious arterial oxygen desaturation and possibly some ventilation perfusion mismatch occur after sedation with intravenously administered meperidine-diazepam for peritoneoscopy with resultant hypoxemia, hypercarbia, and acidosis.

Original languageEnglish (US)
Pages (from-to)1029-1032
Number of pages4
JournalArchives of Internal Medicine
Issue number5
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Internal Medicine


Dive into the research topics of 'Alterations in oxygen saturation and ventilation after intravenous sedation for peritoneoscopy'. Together they form a unique fingerprint.

Cite this