Alterations in lipid levels of mitochondrial membranes induced by amyloid-β: A protective role of melatonin

Sergio A. Rosales-Corral, Gabriela Lopez-Armas, Jose Cruz-Ramos, Valery G. Melnikov, Dun Xian Tan, Lucien C. Manchester, Ruben Munoz, Russel J. Reiter

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Alzheimer pathogenesis involves mitochondrial dysfunction, which is closely related to amyloid-β (Aβ) generation, abnormal tau phosphorylation, oxidative stress, and apoptosis. Alterations in membranal components, including cholesterol and fatty acids, their characteristics, disposition, and distribution along the membranes, have been studied as evidence of cell membrane alterations in AD brain. The majority of these studies have been focused on the cytoplasmic membrane; meanwhile the mitochondrial membranes have been less explored. In this work, we studied lipids and mitochondrial membranes in vivo, following intracerebral injection of fibrillar amyloid-β (Aβ). The purpose was to determine how Aβ may be responsible for beginning of a vicious cycle where oxidative stress and alterations in cholesterol, lipids and fatty acids, feed back on each other to cause mitochondrial dysfunction. We observed changes in mitochondrial membrane lipids, and fatty acids, following intracerebral injection of fibrillar Aβ in aged Wistar rats. Melatonin, a well-known antioxidant and neuroimmunomodulator indoleamine, reversed some of these alterations and protected mitochondrial membranes from obvious damage. Additionally, melatonin increased the levels of linolenic and n-3 eicosapentaenoic acid, in the same site where amyloid β was injected, favoring an endogenous anti-inflammatory pathway

Original languageEnglish (US)
Article number459806
JournalInternational Journal of Alzheimer's Disease
DOIs
StatePublished - 2012

ASJC Scopus subject areas

  • Aging
  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience
  • Behavioral Neuroscience

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    Rosales-Corral, S. A., Lopez-Armas, G., Cruz-Ramos, J., Melnikov, V. G., Tan, D. X., Manchester, L. C., Munoz, R., & Reiter, R. J. (2012). Alterations in lipid levels of mitochondrial membranes induced by amyloid-β: A protective role of melatonin. International Journal of Alzheimer's Disease, [459806]. https://doi.org/10.1155/2012/459806