Abstract
Alterations in intestinal permeability have been postulated to occur after thermal injury. We evaluated the status of intestinal permeability during the first 2 postburn weeks in 15 subjects by measuring the differential excretion of enterally administered lactulose and mannitol. The mean age and burn size of the patients were 32.7 ± 3.6 years and 53.3% ± 5.1% of the total body surface area, respectively. Ten healthy volunteers were also studied. The lactulose-mannitol excretion ratio was 0.159 ± 0.017 for the patients and 0.017 ± 0.003 for controls. The increased ratio did not correlate with burn size or postburn day. Patients who developed significant clinical infections during their first 2 postburn weeks had lactulose-mannitol ratios on postburn day 2 that were significantly higher than those of controls and patients who did not develop infections. This suggests a relationship between susceptibility to infection and early alterations in intestinal permeability.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 26-30 |
| Number of pages | 5 |
| Journal | Archives of Surgery |
| Volume | 127 |
| Issue number | 1 |
| State | Published - 1992 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Surgery
Cite this
Alterations in intestinal permeability after thermal injury. / LeVoyer, T.; Cioffi, W. G.; Pratt, L.; Shippee, R.; McManus, W. F.; Mason, A. D.; Pruitt, Basil A.
In: Archives of Surgery, Vol. 127, No. 1, 1992, p. 26-30.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alterations in intestinal permeability after thermal injury
AU - LeVoyer, T.
AU - Cioffi, W. G.
AU - Pratt, L.
AU - Shippee, R.
AU - McManus, W. F.
AU - Mason, A. D.
AU - Pruitt, Basil A
PY - 1992
Y1 - 1992
N2 - Alterations in intestinal permeability have been postulated to occur after thermal injury. We evaluated the status of intestinal permeability during the first 2 postburn weeks in 15 subjects by measuring the differential excretion of enterally administered lactulose and mannitol. The mean age and burn size of the patients were 32.7 ± 3.6 years and 53.3% ± 5.1% of the total body surface area, respectively. Ten healthy volunteers were also studied. The lactulose-mannitol excretion ratio was 0.159 ± 0.017 for the patients and 0.017 ± 0.003 for controls. The increased ratio did not correlate with burn size or postburn day. Patients who developed significant clinical infections during their first 2 postburn weeks had lactulose-mannitol ratios on postburn day 2 that were significantly higher than those of controls and patients who did not develop infections. This suggests a relationship between susceptibility to infection and early alterations in intestinal permeability.
AB - Alterations in intestinal permeability have been postulated to occur after thermal injury. We evaluated the status of intestinal permeability during the first 2 postburn weeks in 15 subjects by measuring the differential excretion of enterally administered lactulose and mannitol. The mean age and burn size of the patients were 32.7 ± 3.6 years and 53.3% ± 5.1% of the total body surface area, respectively. Ten healthy volunteers were also studied. The lactulose-mannitol excretion ratio was 0.159 ± 0.017 for the patients and 0.017 ± 0.003 for controls. The increased ratio did not correlate with burn size or postburn day. Patients who developed significant clinical infections during their first 2 postburn weeks had lactulose-mannitol ratios on postburn day 2 that were significantly higher than those of controls and patients who did not develop infections. This suggests a relationship between susceptibility to infection and early alterations in intestinal permeability.
UR - http://www.scopus.com/inward/record.url?scp=0026503613&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026503613&partnerID=8YFLogxK
M3 - Article
C2 - 1734847
AN - SCOPUS:0026503613
VL - 127
SP - 26
EP - 30
JO - JAMA Surgery
JF - JAMA Surgery
SN - 2168-6254
IS - 1
ER -