Alterations in intestinal permeability after thermal injury

T. LeVoyer, W. G. Cioffi, L. Pratt, R. Shippee, W. F. McManus, A. D. Mason, Basil A Pruitt

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

Alterations in intestinal permeability have been postulated to occur after thermal injury. We evaluated the status of intestinal permeability during the first 2 postburn weeks in 15 subjects by measuring the differential excretion of enterally administered lactulose and mannitol. The mean age and burn size of the patients were 32.7 ± 3.6 years and 53.3% ± 5.1% of the total body surface area, respectively. Ten healthy volunteers were also studied. The lactulose-mannitol excretion ratio was 0.159 ± 0.017 for the patients and 0.017 ± 0.003 for controls. The increased ratio did not correlate with burn size or postburn day. Patients who developed significant clinical infections during their first 2 postburn weeks had lactulose-mannitol ratios on postburn day 2 that were significantly higher than those of controls and patients who did not develop infections. This suggests a relationship between susceptibility to infection and early alterations in intestinal permeability.

Original languageEnglish (US)
Pages (from-to)26-30
Number of pages5
JournalArchives of Surgery
Volume127
Issue number1
StatePublished - 1992
Externally publishedYes

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Lactulose
Permeability
Mannitol
Hot Temperature
Wounds and Injuries
Infection
Body Surface Area
Healthy Volunteers

ASJC Scopus subject areas

  • Surgery

Cite this

LeVoyer, T., Cioffi, W. G., Pratt, L., Shippee, R., McManus, W. F., Mason, A. D., & Pruitt, B. A. (1992). Alterations in intestinal permeability after thermal injury. Archives of Surgery, 127(1), 26-30.

Alterations in intestinal permeability after thermal injury. / LeVoyer, T.; Cioffi, W. G.; Pratt, L.; Shippee, R.; McManus, W. F.; Mason, A. D.; Pruitt, Basil A.

In: Archives of Surgery, Vol. 127, No. 1, 1992, p. 26-30.

Research output: Contribution to journalArticle

LeVoyer, T, Cioffi, WG, Pratt, L, Shippee, R, McManus, WF, Mason, AD & Pruitt, BA 1992, 'Alterations in intestinal permeability after thermal injury', Archives of Surgery, vol. 127, no. 1, pp. 26-30.
LeVoyer T, Cioffi WG, Pratt L, Shippee R, McManus WF, Mason AD et al. Alterations in intestinal permeability after thermal injury. Archives of Surgery. 1992;127(1):26-30.
LeVoyer, T. ; Cioffi, W. G. ; Pratt, L. ; Shippee, R. ; McManus, W. F. ; Mason, A. D. ; Pruitt, Basil A. / Alterations in intestinal permeability after thermal injury. In: Archives of Surgery. 1992 ; Vol. 127, No. 1. pp. 26-30.
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