Alterations in Intestinal Permeability After Thermal Injury

Cpt Thomas Levoyer, Maj W.G. Cioffi, Cpt Laura Pratt, Maj Ronald Shippee, Col William F. Mcmanus, A. D. Mason, Col B.A. Pruitt

Research output: Contribution to journalArticle

130 Scopus citations

Abstract

Alterations in intestinal permeability have been postulated to occur after thermal injury. We evaluated the status of intestinal permeability during the first 2 postburn weeks in 15 subjects by measuring the differential excretion of enterally administered lactulose and mannitol. The mean age and burn size of the patients were 32.7±3.6 years and 53.3%±5.1% of the total body surface area, respectively. Ten healthy volunteers were also studied. The lactulose-mannitol excretion ratio was 0.159±0.017 for the patients and 0.017±0.003 for controls. The increased ratio did not correlate with burn size or postburn day. Patients who developed significant clinical infections during their first 2 postburn weeks had lactulose-mannitol ratios on postburn day 2 that were significantly higher than those of controls and patients who did not develop infections. This suggests a relationship between susceptibility to infection and early alterations in intestinal permeability.

Original languageEnglish (US)
Pages (from-to)26-30
Number of pages5
JournalArchives of Surgery
Volume127
Issue number1
DOIs
StatePublished - Jan 1992

ASJC Scopus subject areas

  • Surgery

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    Levoyer, C. T., Cioffi, M. W. G., Pratt, C. L., Shippee, M. R., Mcmanus, C. W. F., Mason, A. D., & Pruitt, C. B. A. (1992). Alterations in Intestinal Permeability After Thermal Injury. Archives of Surgery, 127(1), 26-30. https://doi.org/10.1001/archsurg.1992.01420010032005