Alterations in immunological reactivity in encephalomyocarditis virus induced murine diabetes. I. Defective primary IgM plaque forming cell responses to sheep erythrocytes: Correction by islet cell transplantation

B. S. Handwerger, G. Fernandes, T. Riehm, J. W. Yoon, D. E. Sutherland, D. M. Brown

Research output: Contribution to journalArticle

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Abstract

Increasing data suggest a possible viral aetiology of juvenile onset, insulin-dependent diabetes mellitus. The M variant of the encephalomyocarditis (EMC) virus infects murine pancreatic beta cells and causes a diabetes like syndrome in suscepetible strains of mice. Abnormalities in immunological function have been documented in patients with diabetes mellitus and in spontaneous, streptozotocin-induced and alloxan-induced diabetes in animals. The present study documents a significant impairment of the ability of mice with EMC virus (M variant)-induced diabetes to generate a direct, IgM PFC response after in vivo immunization with sheep erythrocytes. This abnormality appears to be a direct consequence of the diabetic state and not EMC virus infection, per se, since (1) mice infected with EMC virus that do not become diabetic have normal direct PFC responses and (2) islet cell transplantation, which cures the diabetes, corrects the defect in PFC responsiveness.

Original languageEnglish (US)
Pages (from-to)145-150
Number of pages6
JournalClinical and Experimental Immunology
Volume60
Issue number1
StatePublished - 1985
Externally publishedYes

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Encephalomyocarditis virus
Islets of Langerhans Transplantation
Cell Transplantation
Islets of Langerhans
Immunoglobulin M
Sheep
Erythrocytes
Experimental Diabetes Mellitus
Insulin-Secreting Cells
Virus Diseases
Streptozocin
Type 1 Diabetes Mellitus
Immunization
Diabetes Mellitus

ASJC Scopus subject areas

  • Immunology

Cite this

Alterations in immunological reactivity in encephalomyocarditis virus induced murine diabetes. I. Defective primary IgM plaque forming cell responses to sheep erythrocytes : Correction by islet cell transplantation. / Handwerger, B. S.; Fernandes, G.; Riehm, T.; Yoon, J. W.; Sutherland, D. E.; Brown, D. M.

In: Clinical and Experimental Immunology, Vol. 60, No. 1, 1985, p. 145-150.

Research output: Contribution to journalArticle

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