Abstract
Acute insulin stress increased plasma catecholamine levels in both the Syrian hamster and albino rat within 3 h after an intraperitoneal injection of either 5 or 10 units of insulin. In the rat, this stress caused a concurrent increase in pineal serotonin N-acetyltransferase (NAT) activity and melatonin content with no observable change in hydroxyindole-O-methyltransferase (HIOMT) activity. In the hamster, on the other hand, acute insulin stress did not alter pineal NAT activity, but depressed both HIOMT activity and melatonin content up to 3 h after the stress. These results present further evidence that catecholamines do not control hamster pineal melatonin synthesis by the same mechanism as observed in the rat.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 25-32 |
| Number of pages | 8 |
| Journal | Brain Research |
| Volume | 338 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 8 1985 |
Keywords
- Syrian hamster
- albino rat
- catecholamines
- melatonin
- pineal
- stress
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology
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Cite this
Champney, T. H., Steger, R. W., Christie, D. S., & Reiter, R. J. (1985). Alterations in components of the pineal melatonin synthetic pathway by acute insulin stress in the rat and Syrian hamster. Brain Research, 338(1), 25-32. https://doi.org/10.1016/0006-8993(85)90244-6