Alteración de los sistemas antinociceptivos en las cefaleas crónicas diarias

Translated title of the contribution: Alteration of the antinociceptive systems in chronic daily headaches

Federico Buonanotte, C. Schurrer, M. Carpinella, A. Surur, A. Marangoni, S. Palacio, M. Forteza, R. Fernández, J. Enders

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Introduction. Chronic daily headache (CDH) is a chronic painful clinical condition that is frequently found in neurological practice. Diagnosis is clinical and the therapeutic approach is complex. Its mechanism of production is still not altogether clear, but a genetic component is acknowledged as a predisposing factor. Numerous areas are involved in the generation of primary headaches, including the periaqueductal grey matter (PAGM), which plays a role as a neuromodulator both in headaches and in other chronic painful conditions. Aims. In order to evaluate possible biochemical changes in patients with CDH, magnetic resonance imaging was used to study the spectra produced in the PAGM. Subjects and methods. The spectra in the PAGM were studied in 17 patients with CDH. These were compared with the average spectra in 17 healthy subjects by means of differential spectroscopy. Results. Subjects with CDH show a reduction of over 70% in the level of the metabolite N-acetyl-aspartyl-glutamate (NAAG) in the PAGM. NAAG is a peptide involved in antinociceptive activity. Conclusions. The reduction of NAAG in the PAGM suggests altered neuromodulation of the antinociceptive systems in subjects with CDH. Whether CDH is the cause or the consequence has still to be determined.

Translated title of the contributionAlteration of the antinociceptive systems in chronic daily headaches
Original languageSpanish
Pages (from-to)263-267
Number of pages5
JournalRevista de Neurologia
Issue number5
StatePublished - Sep 2006
Externally publishedYes


  • Chronic daily headache
  • Migraine
  • N-acetyl-aspartyl-glutamate
  • Periaqueductal gray
  • Spectroscopy

ASJC Scopus subject areas

  • Clinical Neurology


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